Book chapter
The low affinity IgE Fc receptor (CD23) participates in B cell activation
Mechanisms of Lymphocyte Activation and Immune Regulation IV, Vol.323, pp.149-156
Advances in experimental medicine and biology, 323, Plenum Press
1992
DOI: 10.1007/978-1-4615-3396-2_19
PMID: 1485561
Abstract
The low affinity IgE Fc receptor (FcɛRII or CD23) is expressed on all mature B lymphocytes (reviewed in 1 and 2). The FcʵRII is a 45 to 49 KD glycoprotein, and is categorized as a class II transmembrane molecule on account of its inverted membrane orientation. In addition to the transmembrane form of the receptor, a soluble form is readily released from B cells, a result of cleavage by a cell surface protease. cDNA cloning has revealed that the FceRII is a member of the hepatic lectin family, a somewhat unusual finding since all other characterized Fc receptors are known to be members of the immunoglobulin (Ig) gene superfamily.
Details
- Title: Subtitle
- The low affinity IgE Fc receptor (CD23) participates in B cell activation
- Creators
- Thomas J Waldschmidt - Department of Pathology, University of Iowa, College of Medicine, Iowa City 52242Lorraine T Tygrett
- Resource Type
- Book chapter
- Publication Details
- Mechanisms of Lymphocyte Activation and Immune Regulation IV, Vol.323, pp.149-156
- Publisher
- Plenum Press; New York
- Series
- Advances in experimental medicine and biology; 323
- DOI
- 10.1007/978-1-4615-3396-2_19
- PMID
- 1485561
- ISSN
- 0065-2598
- Grant note
- R29AI31265 / NIAID NIH HHS
- Language
- English
- Date published
- 1992
- Academic Unit
- Pathology
- Record Identifier
- 9984047728502771
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