Book chapter
The transforming activity of PP59C-MYC is weaker than that of v-myc
Mechanisms in B-Cell Neoplasia 1990, pp.259-265
Current topics in microbiology and immunology, 166
1990
DOI: 10.1007/978-3-642-75889-8_32
PMID: 2073806
Abstract
We and others have speculated that elevated expression of c-myc plays an important role in the establishment of the transformed follicle, a preneoplastic lesion essential for the development of the ALV-induced bursal-dependent lymphoma (Baba and Humphries 1985, Clurman and Hayward 1989, Neiman et al 1985). The discovery of base substitutions and missense mutations in some tumor c- myc alleles raises the possibility that qualitative as well as quantitative alterations within the chicken c-myc proto-oncogene may play a role in the genesis and/or progression of bursal lymphomas (Westaway et al 1984). In order to assess the contribution that deregulated expression of an unaltered c-myc allele makes during ALV lymphomagenesis (Hayward et al 1981) , we have constructed a recombinant avian retrovirus, SNVc-myc, that encodes the second and third exons of normal chicken c-myc and expresses only the smaller of the two c-myc proto-oncogene products, pp62c-myc and pp59c-myc (Hann et al 1988). Ultimately, this virus will enable the effects of specific mutations within the context of wild-type pp59c-myc to be assessed.
Details
- Title: Subtitle
- The transforming activity of PP59C-MYC is weaker than that of v-myc
- Creators
- E H Humphries - Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235-9048E J Filardo
- Resource Type
- Book chapter
- Publication Details
- Mechanisms in B-Cell Neoplasia 1990, pp.259-265
- Publisher
- Germany
- Series
- Current topics in microbiology and immunology; 166
- DOI
- 10.1007/978-3-642-75889-8_32
- PMID
- 2073806
- ISSN
- 0070-217X
- Grant note
- CA32295 / NCI NIH HHS
- Language
- English
- Date published
- 1990
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Surgery; Internal Medicine
- Record Identifier
- 9984051996502771
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