Book chapter
Therapeutic Applications of Mesenchymal Stem/Multipotent Stromal Cells
Stem Cells & Regenerative Medicine, pp.195-218
Stem Cell Biology and Regenerative Medicine, Humana Press
10/07/2010
DOI: 10.1007/978-1-60761-860-7_12
Abstract
Stem cell therapies offer enormous hope for treating many tragic diseases and tissue defects. In particular, mesenchymal stem/multipotent stromal cells (MSCs) are capable of differentiating into multiple types of connective tissues (i.e., bone, cartilage, and even muscle and neuron) and have proangiogeneic and immunomodulatory effects. MSCs have potential utility for treating a variety of diseases and disorders, including graft versus host disease, problems related to organ transplantation, cardiovascular disease, brain and spinal cord injury, lung, liver, and kidney diseases, and skeletal injuries. This chapter summarizes the current status of therapeutic applications of MSCs. It begins by introducing the basics of MSCs and then focuses on their therapeutic potential, including mechanism of action, delivery routes, MSC homing, the current status of clinical trials, and potential challenges and safety issues. Finally, the chapter describes chemical approaches developed in the authors’ laboratory to promote homing and engraftment of systemically infused MSCs within specific tissues.
Details
- Title: Subtitle
- Therapeutic Applications of Mesenchymal Stem/Multipotent Stromal Cells
- Creators
- Weian Zhao - Department of Medicine, Harvard-MIT Division of Health Sciences and Technology, Brigham and Women’s Hospital, Harvard Medical School and Harvard Stem Cell Institute, Cambridge, USADebanjan SarkarJames AnkrumSean HallWeili LohWei Suong TeoJeffrey M Karp - Department of Medicine, Harvard-MIT Division of Health Sciences and Technology, Brigham and Women’s Hospital, Harvard Medical School and Harvard Stem Cell Institute, Cambridge, USA
- Resource Type
- Book chapter
- Publication Details
- Stem Cells & Regenerative Medicine, pp.195-218
- Publisher
- Humana Press; Totowa, NJ
- Series
- Stem Cell Biology and Regenerative Medicine
- DOI
- 10.1007/978-1-60761-860-7_12
- eISSN
- 2196-8993
- ISSN
- 2196-8985
- Language
- English
- Date published
- 10/07/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984001113902771
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