Book chapter
Toward Translating Molecular Ear Development to Generate Hair Cells from Stem Cells
Adult Stem Cells, pp.111-161
Stem Cell Biology and Regenerative Medicine, Springer New York
02/03/2013
DOI: 10.1007/978-1-4614-9569-7_6
Abstract
The ear develops through the transformation of embryonic ectoderm into the labyrinth and, through a stepwise molecular restriction of cell fate options, into cells neurosensory cells (hair cells, neurons) and non-neurosensory cells. Hair cells can degenerate because of age, ototoxic drugs, acoustic trauma or genetic predisposition. Two principle approaches have been developed to restore hair cells that do not regenerate: a cell-based therapy and a gene-based therapy. One approach recapitulates developmental steps to transform embryonic stem cells into hair cells. Alternatively, gene therapy uses the molecular basis of hair cell development to transform remaining cells into hair cells. We review the molecular basis of normal neurosensory development, the state of cell and gene-based approaches, and indicate future improvements to increase the yield from either adult stem cells or embryonic- or adult-induced pluripotent stem cells (ES and iPS).
Details
- Title: Subtitle
- Toward Translating Molecular Ear Development to Generate Hair Cells from Stem Cells
- Creators
- Azel Zine - Integrative and Adaptive Neurosciences Laboratory, CNRS UMR 7260, Aix-Marseille, University Marseille, Marseille, FranceHubert Löwenheim - Department of Otorhinolaryngology – Head & Neck Surgery, University of Tübingen Medical Center, Tübingen, GermanyBernd Fritzsch - Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, USA
- Resource Type
- Book chapter
- Publication Details
- Adult Stem Cells, pp.111-161
- Series
- Stem Cell Biology and Regenerative Medicine
- DOI
- 10.1007/978-1-4614-9569-7_6
- eISSN
- 2196-8993
- ISSN
- 2196-8985
- Publisher
- Springer New York; New York, NY
- Language
- English
- Date published
- 02/03/2013
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984071678402771
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