Book chapter
Tumor Response Assessment: RECIST and Beyond
Imaging in Pediatric Oncology, pp.157-169
Pediatric Oncology, Springer International Publishing
03/28/2019
DOI: 10.1007/978-3-030-03777-2_9
Abstract
The Response Evaluation Criteria in Solid Tumors (RECIST) guidance was introduced in 2000 and revised as RECIST 1.1 in 2009. RECIST was put together with the goal of standardising and simplifying tumor response criteria. The important role of imaging in response assessment was recognised, and specific imaging guidelines were included. The significant imaging-related changes in RECIST 1.1 in comparison to RECIST 1.0 included a reduction in the number of lesions to be addressed, from a maximum of 10 to a maximum of 5 and from 5 to 2 lesions per organ; assessment of lymph node size; and clarification of what constituted disease progression. The definitions of response within the RECIST guidance are addressed within this chapter in addition to the limitations of using tumor size alone as a biomarker for tumor response. Other methods of assessing tumor response such as response to immunotherapy (iRECIST) and response on PET-CT (PERCIST) are also included.
Details
- Title: Subtitle
- Tumor Response Assessment: RECIST and Beyond
- Creators
- Kieran McHugh - Great Ormond Street HospitalSimon Kao - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Imaging in Pediatric Oncology, pp.157-169
- Publisher
- Springer International Publishing; Cham
- Series
- Pediatric Oncology
- DOI
- 10.1007/978-3-030-03777-2_9
- eISSN
- 2191-0812
- ISSN
- 1613-5318
- Language
- English
- Date published
- 03/28/2019
- Academic Unit
- Radiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984318691502771
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