Book chapter
Tumors of the Adrenal Gland
Pediatric Malignancies: Pathology and Imaging, pp.321-357
Springer New York
10/28/2014
DOI: 10.1007/978-1-4939-1729-7_12
Abstract
Adrenal tumors, classified by their cellular origin and function, may arise from the medulla or cortex. In addition to those located in the adrenal glands, tumors originating from the neural crest may occur anywhere along the sympathetic nervous chain. Those arising from the adrenal medulla or extramedullary sites include neuroblastic tumors (neural crest origin) and the paraganglionic cells (pheochromocytoma and paraganglioma). Those arising from the cortex include adrenocortical carcinoma and adenoma. In this chapter, the initial imaging and pathologic features of the neuroblastic tumors, pheochromocytoma/paraganglioma, and adrenocortical carcinoma are emphasized. The role of imaging modalities from plain radiography and ultrasound to computed tomography, magnetic resonance imaging, and functional radionuclide imaging is discussed, including the relatively new International Neuroblastoma Risk Group Staging System to identify preoperative and pretreatment imaging-defined risk factors. The Pathology section reviews current concepts in histological classification, immunohistochemical markers, cytogenetics, and molecular genetics as pertaining to the diagnosis and prognosis of these tumors.
Details
- Title: Subtitle
- Tumors of the Adrenal Gland
- Creators
- Simon Ching-Shun Kao - University of Iowa Health CareAlfredo Pinto-Rojas - University of Calgary
- Resource Type
- Book chapter
- Publication Details
- Pediatric Malignancies: Pathology and Imaging, pp.321-357
- DOI
- 10.1007/978-1-4939-1729-7_12
- Publisher
- Springer New York; New York, NY
- Language
- English
- Date published
- 10/28/2014
- Academic Unit
- Radiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984318780102771
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