Book chapter
VZV ORF47 Serine Protein Kinase and Its Viral Substrates
Varicella-zoster Virus, pp.99-111
Current Topics in Microbiology and Immunology, 342, Springer
02/26/2010
DOI: 10.1007/82_2009_5
PMID: 20186612
Abstract
ORF47, a serine protein kinase of varicella-zoster virus (VZV) and homolog of herpes simplex virus UL13, is an interesting modulator of VZV pathogenesis. This chapter summarizes research showing that ORF47 protein kinase activity, by virtue of phosphorylation of or binding to various viral substrates, regulates VZV proteins during all phases of viral infection and has a pronounced effect on the trafficking of gE, the predominant VZV glycoprotein, which in turn is critical for cell-to-cell spread of the virus. Casein kinase II, an ubiquitous cellular protein kinase, recognizes a similar but less stringent phosphorylation consensus sequence and can partially compensate for lack of ORF47 activity in VZV-infected cells. Differences between the phosphorylation consensus sites of the viral and cellular kinases are outlined in detail.
Details
- Title: Subtitle
- VZV ORF47 Serine Protein Kinase and Its Viral Substrates
- Creators
- Teri K Kenyon - Department of Pediatrics/2501 JCP, University of Iowa Hospital, Iowa City, USACharles Grose - Department of Pediatrics/2501 JCP, University of Iowa Hospital, Iowa City, USA
- Resource Type
- Book chapter
- Publication Details
- Varicella-zoster Virus, pp.99-111
- Publisher
- Springer; Berlin, Heidelberg
- Series
- Current Topics in Microbiology and Immunology; 342
- DOI
- 10.1007/82_2009_5
- PMID
- 20186612
- ISSN
- 0070-217X
- Language
- English
- Date published
- 02/26/2010
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093366202771
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