Review
Assessment of Blood Flow in Solid Tumors Using PET
Clinical Positron Imaging, Vol.1(2), pp.117-121
1998
DOI: 10.1016/S1095-0397(98)00006-5
PMID: 14516600
Abstract
Objective: To develop a technique for the evaluation of tumor perfusion prior to and during chemo- and radiation therapy.
Methods: Using the [
15O]water autoradiographic technique and positron emission tomography (PET), perfusion in solid cervical tumors was investigated in a series of women
N = 7
prior to and during radiation therapy for cervical cancer. A 60-second summed image was used with the arterial blood curve to create a parametric image. The parametric images were registered to sagittal magnetic resonance (MR) images. Regions drawn on the MR images encompassing the tumor were transferred to the corresponding co-registered PET images.
Results: All tumors were easily visualized by both imaging modalities and tissue heterogeneity could be evaluated. Mean pre- and during therapy flow values averaged 41.5 ± 11.9 and 48.2 ± 7.2 mL/min/100 g tumor, respectively.
Conclusions: Perfusion status of solid tumors, an assumed predictor of response potential, can be assessed using PET and the [
15O]water technique.
Details
- Title: Subtitle
- Assessment of Blood Flow in Solid Tumors Using PET
- Creators
- Laura L.B Ponto - P.E.T. Imaging Center, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa USAMark T Madsen - P.E.T. Imaging Center, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa USARichard D Hichwa - P.E.T. Imaging Center, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa USANina Mayr - P.E.T. Imaging Center, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa USAWilliam T.C Yuh - P.E.T. Imaging Center, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa USAVincent A Magnotta - P.E.T. Imaging Center, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa USAG.Leonard Watkins - P.E.T. Imaging Center, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa USAJames C Ehrhardt - P.E.T. Imaging Center, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa USA
- Resource Type
- Review
- Publication Details
- Clinical Positron Imaging, Vol.1(2), pp.117-121
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S1095-0397(98)00006-5
- PMID
- 14516600
- ISSN
- 1095-0397
- Language
- English
- Date published
- 1998
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984051507802771
Metrics
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