Review
Protein trafficking in the exocytic pathway of polarized epithelial cells
Trends in Cell Biology, Vol.11(12), pp.483-486
2001
DOI: 10.1016/S0962-8924(01)02145-6
PMID: 11719053
Abstract
Ten years ago, we knew much about the function of polarized epithelia from the work of physiologists, but, as cell biologists, our understanding of how these cells were constructed was poor. We knew proteins were sorted and targeted to different plasma membrane domains and that, in some cells, the Golgi was the site of sorting, but we did not know the mechanisms involved. Between 1991 and the present, significant advances were made in defining sorting motifs for apical and basal-lateral proteins, describing the sorting machinery in the
trans-Golgi network (TGN) and plasma membrane, and in understanding how cells specify delivery of transport vesicles to different membrane domains. The challenge now is to extend this knowledge to defining molecular mechanisms in detail
in vitro and comprehending the development of complex epithelial structures
in vivo.
Details
- Title: Subtitle
- Protein trafficking in the exocytic pathway of polarized epithelial cells
- Creators
- W.James Nelson - Dept of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305-5435, USACharles Yeaman - Dept of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305-5435, USA
- Resource Type
- Review
- Publication Details
- Trends in Cell Biology, Vol.11(12), pp.483-486
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0962-8924(01)02145-6
- PMID
- 11719053
- ISSN
- 0962-8924
- eISSN
- 1879-3088
- Language
- English
- Date published
- 2001
- Academic Unit
- Anatomy and Cell Biology; Internal Medicine
- Record Identifier
- 9984025680702771
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