Traumatic brain injury (TBI) affects 1.7 million people each year, and of these injuries 52,000 result in death. Unfortunately, current TBI research has been relatively unsuccessful in developing possible drug treatments to counteract the secondary injuries which occur after the initial onset of injury. Therapeutic clinical trials targeting the pathophysiological mechanisms of TBI have been difficult to design and carry out because of three main challenges affecting the translation of basic research to clinical research: selecting an animal model that mimics all aspects of human TBI, the existence of narrow therapeutic concentration windows for neuroprotective agents, and identifying an effective therapeutic target (e.g., metabolic pathway) or pharmacological approach (e.g., route of administration).
Conference poster
Bench to Bedside: Current Challenges in TBI Research
SURF 2011 (Spring Undergraduate Research Festival) (Iowa City, Iowa)
03/26/2011
Abstract
Details
- Title: Subtitle
- Bench to Bedside: Current Challenges in TBI Research
- Creators
- Lauren Jones - University of Iowa
- Contributors
- Gerene Denning (Mentor) - Carver College of Medicine
- Resource Type
- Conference poster
- Conference
- SURF 2011 (Spring Undergraduate Research Festival) (Iowa City, Iowa)
- Copyright
- Copyright © 2011 Lauren Jones
- Grant note
- ICRU Research Fellow Award
- Comment
- Major: Biology, Medicine, Psychology. Minor: French
- Language
- English
- Date presented
- 03/26/2011
- Academic Unit
- Iowa Center for Research by Undergraduates; Emergency Medicine
- Record Identifier
- 9984110031402771
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