Conference poster
Poster 11: Striatal Volume Distinguishes Converters from Non-Converters: Findings from PREDICT-HD
Neurotherapeutics, Vol.7(1), pp.141-141
Elsevier Inc
01/2010
DOI: 10.1016/j.nurt.2009.09.013
Abstract
To present data from 32 converter participants and 80 matched non-converter participants from the PREDICT-HD study.
All participants were prodromal when they enrolled in the study and all were examined yearly for at least one visit following enrollment. Converters were defined as those individuals who, on at least two consecutive visits, received a score of 4 on the HD Diagnostic Confidence Scale of the UHDRS. Non-converters were individuals who had at least two visits and never received a score of 4. Converters and non-converters were group-matched on age, gender, and CAG repeat length. MRI measurements were obtained for 4 converters 2 years before diagnosis, for 11 converters 1 year before diagnosis, and for 17 converters at the same visit that the diagnosis was made.
After correcting for intracranial volume (ICV), converters had significantly smaller total brain volume (p = 0.001), total white matter volume (p = 0.004), and total striatum volume (p < 0.0001), but did not differ on size of cerebellum. A logistic regression model was performed with age and gender included first, with the model selecting the remaining variables one by one. The ratio of striatum/ICV was the only variable selected yielding significant discrimination between converters and non-converters (p < 0.0001), with correct classification of 78.2% of participants. None of the other MRI measures provided additional significant predictive value to the model. Results indicate that striatal volume, as assessed on MRI, but not other brain measures examined, contributes additional information beyond age and CAG repeat length in predicting onset of diagnosable HD signs. This information, assuming replication in larger samples, highlights the importance of striatal atrophy in the neurobiology of HD, and will be useful for designing clinical trials in which diagnosis of HD is the primary outcome measure.
Details
- Title: Subtitle
- Poster 11: Striatal Volume Distinguishes Converters from Non-Converters: Findings from PREDICT-HD
- Creators
- E Aylward - Seattle Children's Research Institute, Seattle, WA, USAP Nopoulos - University of Iowa, Iowa City, IA, USAC Ross - Johns Hopkins University, Baltimore, MD, USAR Pierson - University of Iowa, Iowa City, IA, USAJ Mills - University of Iowa, Iowa City, IA, USAD Langbehn - University of Iowa, Iowa City, IA, USAV Magnotta - University of Iowa, Iowa City, IA, USAH Johnson - University of Iowa, Iowa City, IA, USAJ Paulsen - University of Iowa, Iowa City, IA, USA
- Resource Type
- Conference poster
- Publication Details
- Neurotherapeutics, Vol.7(1), pp.141-141
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.nurt.2009.09.013
- ISSN
- 1933-7213
- eISSN
- 1878-7479
- Language
- English
- Date published
- 01/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Iowa Neuroscience Institute; Electrical and Computer Engineering; Neurology; Stead Family Department of Pediatrics; Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984066393602771
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