Conference poster
Poster 5: An Item Response Analysis of Depressive Symptomatology in Pre-Huntington Disease
Neurotherapeutics, Vol.6(1), pp.205-205
Elsevier Inc
2009
DOI: 10.1016/j.nurt.2008.10.006
Abstract
Historically, the diagnosis of HD has been based on the presence of motor-related symptoms. There is emerging evidence, however, that prior to the manifestation of motor symptoms sufficient to warrant clinical diagnosis, many patients exhibit subtle motor, cognitive, and psychiatric signs, suggesting that people with HD may experience detectable changes before clinical diagnosis (i.e., pre-HD).
There is currently a need for a rating scale that is sensitive enough to detect early symptomatic changes and disease progression in pre-HD. The Functional Rating Scale Taskforce for pre-HD (FuRST-pHD) has been established to develop such a measure. In the initial phase of this program, FuRST-pHD will identify which symptoms should be addressed in a clinical scale, and how best to measure those symptoms.
Depression is thought to be a component of HD that may be present prior to clinical diagnosis. In the present study, FuRST-pHD examined the expression of signs and symptoms associated with depression using data obtained from PREDICT-HD, utilizing a non-parametric item response analysis of depression ratings (UHDRS-III, BDI-II). Item response modeling can be used to evaluate the performance of individual items (or symptoms) on rating scales, assessing the relationship between a score assigned to a particular item and overall severity of the disease.
The results show that pre-HD CAG-expanded subjects (≥37 repeats, n = 752) reported greater depressive symptomatology compared to the comparison group (<30 repeats, n = 181). Depression-related symptoms generally increased as a function of overall depressive severity, with six UHDRS-III items (Depressed Mood, Guilt/Self-Esteem, Apathy, Anxiety, Irritability and Anger) and seven BDI items (Sadness, Loss of Pleasure, Guilt, Loss of Energy, Irritability, Concentration, and Fatigue) showing good relation between item score and overall severity. These depression-related signs and symptoms warrant further assessment as items to include on a scale to assess pre-HD symptoms. FuRST-pHD is sponsored by CHDI Foundation.
Details
- Title: Subtitle
- Poster 5: An Item Response Analysis of Depressive Symptomatology in Pre-Huntington Disease
- Creators
- A Vaccarino - Ontario Cancer Biomarker Network, Toronto, Ontario, CanadaK Anderson - University of Maryland, Baltimore, MD, USAB Borowsky - CHDI Foundation, Princeton, NJ, USAK Duff - University of Iowa, Iowa City, IA, USAK Evans - Ontario Cancer Biomarker Network, Toronto, Ontario, CanadaJ Giuliano - CHDI Foundation, Princeton, NJ, USAM Guttman - The Center for Movement Disorders, Markham, Ontario, CanadaA Ho - University of Reading, Reading, UKD Langbehn - University of Iowa, Iowa City, IA, USAJ Paulsen - University of Iowa, Iowa City, IA, USAT Sills - Ontario Cancer Biomarker Network, Toronto, Ontario, CanadaD Van Kammen - CHDI Foundation, Princeton, NJ, USA
- Resource Type
- Conference poster
- Publication Details
- Neurotherapeutics, Vol.6(1), pp.205-205
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.nurt.2008.10.006
- ISSN
- 1933-7213
- eISSN
- 1878-7479
- Language
- English
- Date published
- 2009
- Academic Unit
- Iowa Neuroscience Institute; Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984066378102771
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