Conference proceeding
A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat
Acta physiologica scandinavica, Vol.177(3), pp.345-349
APS International Symposium on Sympathetic Neural Mechanisms in Cardiovascular Control
2003
DOI: 10.1046/j.1365-201X.2003.01085.x
PMID: 12609005
Abstract
Aim: This manuscript briefly reviews evidence and potential implications of a leptin-sympathetic-leptin feedback loop.
Results: Leptin increases sympathetic nerve activity to brown adipose tissue, kidney and other tissues. This action has implications for regulation of arterial pressure. In turn, there is evidence that sympathoadrenal stimulation inhibits leptin mRNA expression and secretion from white adipose tissue through beta adrenergic mechanisms.
Conclusion: This sympathetic modulation of leptin expression has potential implications for regulation of body fat.
Details
- Title: Subtitle
- A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat
- Creators
- A. L MARK - Specialized Center of Research in Hypertension Genetics; the Department of Intemal Medicine; and the Cardiovascular Research Center at the University of Iowa Roy J. and Lucille A, Carver College of Medicine, and the Veterans Administration Medical Ce, Iowa City, IA, United StatesK RAHMOUNI - Specialized Center of Research in Hypertension Genetics; the Department of Intemal Medicine; and the Cardiovascular Research Center at the University of Iowa Roy J. and Lucille A, Carver College of Medicine, and the Veterans Administration Medical Ce, Iowa City, IA, United StatesM CORREIA - Specialized Center of Research in Hypertension Genetics; the Department of Intemal Medicine; and the Cardiovascular Research Center at the University of Iowa Roy J. and Lucille A, Carver College of Medicine, and the Veterans Administration Medical Ce, Iowa City, IA, United StatesW. G HAYNES - Specialized Center of Research in Hypertension Genetics; the Department of Intemal Medicine; and the Cardiovascular Research Center at the University of Iowa Roy J. and Lucille A, Carver College of Medicine, and the Veterans Administration Medical Ce, Iowa City, IA, United States
- Resource Type
- Conference proceeding
- Publication Details
- Acta physiologica scandinavica, Vol.177(3), pp.345-349
- Conference
- APS International Symposium on Sympathetic Neural Mechanisms in Cardiovascular Control
- Publisher
- Blackwell Science; Oxford
- DOI
- 10.1046/j.1365-201X.2003.01085.x
- PMID
- 12609005
- ISSN
- 0001-6772
- eISSN
- 1365-201X
- Grant note
- Scandinavian Physiological Society
- Language
- English
- Date published
- 2003
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984040388302771
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