Conference proceeding
A new osteophyte segmentation method with applications to an anterior cruciate ligament transection rabbit femur model via micro-CT imaging
Proceedings of SPIE, Vol.7623(1), pp.76234F-76234F-12
Medical Imaging 2010: Image Processing
03/05/2010
DOI: 10.1117/12.844440
Abstract
Osteophyte is an additional bony growth on a normal bone surface limiting or stopping motion in a deteriorating joint.
Detection and quantification of osteophytes from CT images is helpful in assessing disease status as well as treatment and
surgery planning. However, it is difficult to segment osteophytes from healthy bones using simple thresholding or
edge/texture features in CT imaging. Here, we present a new method, based on active shape model (ASM), to solve this
problem and evaluate its application to ex vivo CT images in an ACLT rabbit femur model. The common idea behind
most ASM based segmentation methods is to first build a parametric shape model from a training dataset and during
application, find a shape instance from the model that optimally fits to target image. However, it poses a fundamental
difficulty for the current application because a diseased bone shape is significantly altered at regions with osteophyte
deposition misguiding an ASM method that eventually leads to suboptimum segmentation results. Here, we introduce a
new partial ASM method that uses bone shape over healthy regions and extrapolate its shape over diseased region
following the underlying shape model. Once the healthy bone region is detected, osteophyte is segmented by subtracting
partial-ASM derived shape from the overall diseased shape. Also, a new semi-automatic method is presented in this paper
for efficiently building a 3D shape model for rabbit femur. The method has been applied to CT images of 2-, 4-, and
8-week post ACLT and sham-treated rabbit femurs and results of reproducibility and sensitivity analyses of the new
osteophyte segmentation method are presented.
Details
- Title: Subtitle
- A new osteophyte segmentation method with applications to an anterior cruciate ligament transection rabbit femur model via micro-CT imaging
- Creators
- G Liang - University of IowaJ. M Elkins - University of IowaA Coimbra - Merck & Co.L. T Duong - Merck & Co.D. S Williams - Merck & Co.M Sonka - University of IowaP. K Saha - University of Iowa
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.7623(1), pp.76234F-76234F-12
- Conference
- Medical Imaging 2010: Image Processing
- DOI
- 10.1117/12.844440
- ISSN
- 0277-786X
- Language
- English
- Date published
- 03/05/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Orthopedics and Rehabilitation; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984186600602771
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