Conference proceeding
A superpixel-histogram method to analyze retinal, optic nerve, and choroidal blood flow using laser speckle flowgraphy
Vol.12036, pp.1203622-1203622-6
04/04/2022
DOI: 10.1117/12.2611850
Abstract
Laser speckle flowgraphy (LSFG) is a non-invasive imaging technology for quantifying microvascular blood flow. In the eye, LSFG quantifies the relative dynamics of blood flow of the retina, choroid and optic nerve head on a continuous scale. Currently, LSFG analysis requires the placement of “rubber bands” (defining regions of interest) to measure blood flow at desired locations. However, the placement of rubber bands requires knowledge of which regions are likely to be affected by disease. Here, we demonstrate a fully automated superpixel-histogram method without rubber band placement to determine regional blood flow abnormalities. Regional blood flow patterns were quantified via superpixel distributions of mean blur rate (MBR, linearly proportional to blood flow) and percentages of total superpixels at five pre-defined ranges of blood flow. We applied the proposed method to help diagnose acute arteritic anterior ischemic optic neuropathy (AAION) and found that compared to normal eyes, acute AAION eyes showed a significant blood flow reduction of the choroid due to the effect of giant cell arteritis on the posterior ciliary arteries (supplying the choroid and optic nerve circulation). The proposed method demonstrated a novel approach for quantifying abnormal regions of blood flow in different vascular beds caused by disease.
Details
- Title: Subtitle
- A superpixel-histogram method to analyze retinal, optic nerve, and choroidal blood flow using laser speckle flowgraphy
- Creators
- Jui-Kai Wang - Iowa City VA Ctr. for the Prevention and Treatment of Visual Loss (United States)Michelle R. Tamplin - University of IowaMona K. Garvin - Iowa City VA Ctr. for the Prevention and Treatment of Visual Loss (United States)Isabella M. Grumbach - Iowa City VA Ctr. for the Prevention and Treatment of Visual Loss (United States)Randy H. Kardon - Iowa City VA Ctr. for the Prevention and Treatment of Visual Loss (United States)
- Contributors
- Barjor S. Gimi (Editor) - Trinity Health Corp. (United States)Andrzej Krol (Editor) - SUNY Upstate Medical University
- Resource Type
- Conference proceeding
- Publication Details
- Vol.12036, pp.1203622-1203622-6
- Publisher
- SPIE
- DOI
- 10.1117/12.2611850
- ISSN
- 1605-7422
- Language
- English
- Date published
- 04/04/2022
- Academic Unit
- Electrical and Computer Engineering; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences; Internal Medicine; Cardiovascular Medicine; Radiation Oncology
- Record Identifier
- 9984259335202771
Metrics
55 Record Views