Conference proceeding
Active index model: a unique approach for regional quantitative morphometry in longitudinal and cross-sectional studies
Proceedings of SPIE, Vol.6512(1), pp.65121B-65121B-12
Medical Imaging 2007: Image Processing
03/08/2007
DOI: 10.1117/12.709022
Abstract
Recent advancements in digital medical imaging have opened avenues for quantitative analyses of different volumetric and morphometric indices in response to a disease or a treatment. However, a major challenge in performing such an analysis is the lack of a technology of building
that allows mapping data of a given subject onto MAS. This approach leads to a tool for point-by-point regional analysis and comparison of quantitative indices for data coming from a longitudinal or transverse study. Toward this goal, we develop a new computation technique, called
, which is a unique tool to solve the stated problem. AIM consists of three building blocks - (1) development of MAS for a particular anatomic site, (2) mapping a specific data onto MAS, (3) regional statistical analysis of data from different populations assessing regional response to a disease or treatment progression. The AIM presented here is built at the training phase from two known populations (e.g., normal and diseased) which will be immediately ready for diagnostic purpose in a subject whose clinical status is unknown. AIM will be useful for both cross sectional and longitudinal studies and for early diagnostic. This technique will be a vital tool for understanding regional response of a disease or treatment at various stages of its progression. This method has been applied for analyzing regional trabecular bone structural distribution in rabbit femur via micro-CT imaging and to localize the affected myocardial regions from cardiac MR data.
Details
- Title: Subtitle
- Active index model: a unique approach for regional quantitative morphometry in longitudinal and cross-sectional studies
- Creators
- P. K Saha - Univ. of IowaH Zhang - Univ. of IowaM Sonka - Univ. of IowaG. E Christensen - Univ. of IowaC. S Rajapakse - Univ. of Pennsylvania
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.6512(1), pp.65121B-65121B-12
- Conference
- Medical Imaging 2007: Image Processing
- DOI
- 10.1117/12.709022
- ISSN
- 0277-786X
- Language
- English
- Date published
- 03/08/2007
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Radiation Oncology; Radiation Research Laboratory; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984051876302771
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