Conference proceeding
An image-based computational model of ovine lung mechanics and ventilation distribution
Proceedings of SPIE, Vol.5746(1), pp.84-91
Medical Imaging 2005: Physiology, Function, and Structure from Medical Images
04/14/2005
DOI: 10.1117/12.600723
Abstract
A computational model of soft tissue mechanics and air flow has been developed with the aim of linking computed tomography measures of ventilation distribution to subject-specific predictions in image-based geometric (finite element) models of the lung and airway tree. Computational techniques that can deal with anatomical detail and spatially-distributed non-linear material properties have been used to couple solution of parenchymal soft tissue mechanics in an anatomically-based model of the ovine lung to predictions of flow and pressure in an embedded model of the ovine airway tree. The lung is modeled as a homogeneous, compressible, non-linear elastic body. Using equations for large deformation mechanics, the change in geometry of the lung is simulated at static inflation pressures from 25 to 0 cmH
O. Multi-detector row computed tomography imaging has been used to define the model geometry (lung and airway), to define the movement of the model lung surface during inflation, and for measurements of internal material point displacements for comparison with the predicted internal displacements of the model. This preliminary model predicts airway bifurcation point displacements that are generally in agreement with imaged displacements (total RMS error for all bifurcation points is < 4 mm from 25 to 0 cm H
O). Further development of the model will provide a predictive link between subject-specific anatomical and functional information.
Details
- Title: Subtitle
- An image-based computational model of ovine lung mechanics and ventilation distribution
- Creators
- Merryn H Tawhai - University of AucklandMartyn P Nash - University of AucklandJuerg Tschirren - University of IowaEric A Hoffman - University of IowaPeter J Hunter - University of Auckland
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.5746(1), pp.84-91
- Conference
- Medical Imaging 2005: Physiology, Function, and Structure from Medical Images
- DOI
- 10.1117/12.600723
- ISSN
- 0277-786X
- eISSN
- 1996-756X
- Language
- English
- Date published
- 04/14/2005
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318813602771
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