Conference proceeding
Analysis of the Interdependencies Among Plaque Development, Vessel Curvature, and Wall Shear Stress in Coronary Arteries
Functional Imaging and Modeling of the Heart, pp.12-22
Lecture Notes in Computer Science
2005
DOI: 10.1007/11494621_2
Abstract
The relationships among vascular geometry, hemodynamics, and plaque development in coronary arteries are not yet well understood. This in-vivo study was based on the observation that plaque frequently develops at the inner curvature of a vessel, presumably due to a relatively lower wall shear stress. We have shown that circumferential plaque distribution depends on the vessel curvature in the majority of vessels. Consequently, we studied the correlation of plaque distribution and hemodynamics in a set of 48 vessel segments reconstructed by 3-D fusion of intravascular ultrasound and x-ray angiography. The inverse relationship between local wall shear stress and plaque thickness was significantly more pronounced (p<0.025) in vessel cross sections exhibiting compensatory enlargement (positive remodeling) without luminal narrowing than when the full spectrum of vessel stenosis severity was considered. Our findings confirmed that relatively lower wall shear stress is associated with increased plaque development.
Details
- Title: Subtitle
- Analysis of the Interdependencies Among Plaque Development, Vessel Curvature, and Wall Shear Stress in Coronary Arteries
- Creators
- Andreas Wahle - Department of Electrical and Computer Engineering,John J Lopez - Department of Medicine, The University of Chicago, Chicago, USAMark E Olszewski - Department of Electrical and Computer Engineering,Sarah C Vigmostad - Department of Biomedical Engineering,Krishnan B Chandran - Department of Biomedical Engineering,James D Rossen - Department of Internal Medicine, The University of Iowa, Iowa City, USAMilan Sonka - Department of Electrical and Computer Engineering,
- Resource Type
- Conference proceeding
- Publication Details
- Functional Imaging and Modeling of the Heart, pp.12-22
- Series
- Lecture Notes in Computer Science
- DOI
- 10.1007/11494621_2
- eISSN
- 1611-3349
- ISSN
- 0302-9743
- Publisher
- Springer Berlin Heidelberg; Berlin, Heidelberg
- Language
- English
- Date published
- 2005
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Electrical and Computer Engineering; Cardiovascular Medicine; Surgery; Radiation Oncology; Injury Prevention Research Center; Neurosurgery; Mechanical Engineering; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984047606202771
Metrics
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