Conference proceeding
Analysis of trabecular bone architectural changes induced by osteoarthritis in rabbit femur using 3D active shape model and digital topology
Proceedings of SPIE, Vol.6511(1), pp.65110J-65110J-12
Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
03/08/2007
DOI: 10.1117/12.709064
Abstract
Osteoarthritis (OA) is the most common chronic joint disease, which causes the cartilage between the bone joints to wear away, leading to pain and stiffness. Currently, progression of OA is monitored by measuring joint space width using x-ray or cartilage volume using MRI. However, OA affects all periarticular tissues, including cartilage and bone. It has been shown previously that in animal models of OA, trabecular bone (TB) architecture is particularly affected. Furthermore, relative changes in architecture are dependent on the depth of the TB region with respect to the bone surface and main direction of load on the bone. The purpose of this study was to develop a new method for accurately evaluating 3D architectural changes induced by OA in TB. Determining the TB test domain that represents the same anatomic region across different animals is crucial for studying disease etiology, progression and response to therapy. It also represents a major technical challenge in analyzing architectural changes. Here, we solve this problem using a new active shape model (ASM)-based approach. A new and effective semi-automatic landmark selection approach has been developed for rabbit distal femur surface that can easily be adopted for many other anatomical regions. It has been observed that, on average, a trained operator can complete the user interaction part of landmark specification process in less than 15 minutes for each bone data set. Digital topological analysis and fuzzy distance transform derived parameters are used for quantifying TB architecture. The method has been applied on micro-CT data of excised rabbit femur joints from anterior cruciate ligament transected (ACLT) (n = 6) and sham (n = 9) operated groups collected at two and two-to-eight week post-surgery, respectively. An ASM of the rabbit right distal femur has been generated from the sham group micro-CT data. The results suggest that, in conjunction with ASM, digital topological parameters are suitable for analyzing architectural changes induced by OA.
Details
- Title: Subtitle
- Analysis of trabecular bone architectural changes induced by osteoarthritis in rabbit femur using 3D active shape model and digital topology
- Creators
- P. K Saha - University of IowaC. S Rajapakse - University of PennsylvaniaD. S Williams - Merck & Co.L Duong - Merck & Co.A Coimbra - Merck & Co.
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.6511(1), pp.65110J-65110J-12
- Conference
- Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
- DOI
- 10.1117/12.709064
- ISSN
- 0277-786X
- Language
- English
- Date published
- 03/08/2007
- Academic Unit
- Electrical and Computer Engineering; Radiology
- Record Identifier
- 9984197452002771
Metrics
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