Conference proceeding
Assessment of Lung Biomechanics in COPD Using Image Registration
2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), Vol.2020-, pp.1891-1895
04/2020
DOI: 10.1109/ISBI45749.2020.9098501
Abstract
Lung biomechanical properties can be used to detect disease, assess abnormal lung function, and track disease progression. In this work, we used computed tomography (CT) imaging to measure three biomechanical properties in the lungs of subjects with varying degrees of chronic obstructive pulmonary disease (COPD): the Jacobian determinant (J), a measure of volumetric expansion or contraction; the anisotropic deformation index (ADI), a measure of the magnitude of anisotropic deformation; and the the slab-rod index (SRI), a measure of the nature of anisotropy (i.e., whether the volume is deformed to a rod-like or slab-like shape). We analyzed CT data from 247 subjects collected as part of the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). The results show that mean J and mean ADI decrease as disease severity increases, indicating less volumetric expansion and more isotropic expansion with increased disease. No differences in average SRI index were observed across the different levels of disease. The methods and analysis described in this study may provide new insights into our understanding of the biomechanical behavior of the lung for COPD patients with various Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages.
Details
- Title: Subtitle
- Assessment of Lung Biomechanics in COPD Using Image Registration
- Creators
- Yue Pan - University of IowaGary E Christensen - University of IowaOguz C Durumeric - University of IowaSarah E Gerard - Brigham and Women's HospitalSurya P Bhatt - University of Alabama at BirminghamR. Graham Barr - Columbia University Irving Medical CenterEric A Hoffman - University of IowaJoseph M Reinhardt - University of Iowa
- Resource Type
- Conference proceeding
- Publication Details
- 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), Vol.2020-, pp.1891-1895
- Publisher
- IEEE
- DOI
- 10.1109/ISBI45749.2020.9098501
- ISSN
- 1945-7928
- eISSN
- 1945-8452
- Language
- English
- Date published
- 04/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Internal Medicine; Radiology; Radiation Research Laboratory; The Iowa Institute for Biomedical Imaging; Advanced Pulmonary Physiomic Imaging Laboratory; Holden Comprehensive Cancer Center; Radiation Oncology; Mathematics; Electrical and Computer Engineering
- Record Identifier
- 9984196975402771
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