Assessment of plaque stability by means of high-resolution MRI and finite element analyses of local stresses and strains

C Schulze-Bauer; M Auer; R Stollberger; P Regitnig; M Sonka; G.A Holzapfel

doi:10.1109/ISBI.2002.1029291

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Conference proceeding

Assessment of plaque stability by means of high-resolution MRI and finite element analyses of local stresses and strains

C Schulze-Bauer, M Auer, R Stollberger, P Regitnig, M Sonka and G.A Holzapfel

Proceedings IEEE International Symposium on Biomedical Imaging, Vol.2002-, pp.449-452

2002

DOI: 10.1109/ISBI.2002.1029291

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Abstract

To date no adequate diagnostic strategy exists for the assessment of plaque stability. Current approaches focus on identification of high-risk morphological features in cross-sectional images, such as thin caps and large lipid pools. Plaque stability, however, is a 3D mechanical problem, whose solution requires information on both the geometry and the mechanical properties of the involved tissue components. This preliminary in vitro study is aimed to create multicomponent morphological and material models of human diseased arteries from cadavers. Morphological models are based on highly resolved MR images. Material models are fitted to mechanical testing data of single tissue components. Subsequent finite element analysis allows computation of local stresses and strains, whereas consideration of fracture properties provides a basis for the plaque stability assessment. Results demonstrate the complex mechanical behavior of diseased arteries, suggesting that reliable plaque stability assessment requires a combination of appropriate MR protocols, segmentation algorithms and mechanical analysis.

Arteries

Biological materials

Capacitive sensors

Finite element methods

Information geometry

Lipidomics

Magnetic resonance imaging

Mechanical factors

Stability analysis

Stress

Details

Title: Subtitle: Assessment of plaque stability by means of high-resolution MRI and finite element analyses of local stresses and strains
Creators: C Schulze-Bauer - Inst. for Struct. Anal., Computational Biomech., Graz Univ. of Technol., Austria
M Auer - Graz University of Technology
R Stollberger - Institute of Medical Engineering (7170)
P Regitnig - University of Graz
M Sonka - University of Iowa
G.A Holzapfel - Institute of Biomechanics (7190)
Resource Type: Conference proceeding
Publication Details: Proceedings IEEE International Symposium on Biomedical Imaging, Vol.2002-, pp.449-452
DOI: 10.1109/ISBI.2002.1029291
ISSN: 1945-7928
eISSN: 1945-8452
Publisher: IEEE
Language: English
Date published: 2002
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9984186589102771

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