Conference proceeding
Automated 4D lung computed tomography reconstruction during free breathing for conformal radiation therapy
Proceedings of SPIE, Vol.5369(1), pp.100-106
Medical Imaging 2004: Physiology, Function, and Structure from Medical Images
04/30/2004
DOI: 10.1117/12.536141
Abstract
We are developing 4D-CT to provide breathing motion information (trajectories) for radiation therapy treatment planning of lung cancer. Potential applications include optimization of intensity-modulated beams in the presence of breathing motion and intra-fraction target volume margin determination for conformal therapy. The images are acquired using a multi-slice CT scanner while the patient undergoes simultaneous quantitative spirometry. At each couch position, the CT scanner is operated in cin mode and acquires up to 15 scans of 12 slices each. Each CT scan is associated with the measured tidal volume for retrospective reconstruction of 3D CT scans at arbitrary tidal volumes. The specific tasks of this project involves the development of automated registration of internal organ motion (trajectories) during breathing. A modified least-squares based optical flow algorithm tracks specific features of interest by modifying the eigenvalues of gradient matrix (gradient structural tensor). Good correlations between the measured motion and spirometry-based tidal volume are observed and evidence of internal hysteresis is also detected.
Details
- Title: Subtitle
- Automated 4D lung computed tomography reconstruction during free breathing for conformal radiation therapy
- Creators
- Issam M El Naqa - Washington University in St. LouisDaniel A Low - Washington University in St. LouisGary E Christensen - University of IowaParag J Parikh - Washington University in St. LouisJoo Hyun Song - University of IowaMichelle M Nystrom - Washington University in St. LouisWei Lu - Washington University in St. LouisJoseph O Deasy - Washington University in St. LouisJames P Hubenschmidt - Washington University in St. LouisSasha H Wahab - Washington University in St. LouisSasa Mutic - Washington University in St. LouisAnurag K Singh - Washington University in St. LouisJeffrey D Bradley - Washington University in St. Louis
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.5369(1), pp.100-106
- Conference
- Medical Imaging 2004: Physiology, Function, and Structure from Medical Images
- DOI
- 10.1117/12.536141
- ISSN
- 0277-786X
- Language
- English
- Date published
- 04/30/2004
- Academic Unit
- Electrical and Computer Engineering; Radiation Oncology; Radiation Research Laboratory; The Iowa Institute for Biomedical Imaging; Advanced Pulmonary Physiomic Imaging Laboratory; Holden Comprehensive Cancer Center
- Record Identifier
- 9984197306302771
Metrics
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