Conference proceeding
Circadian pattern to arrhythmias in a genetic mouse model of heart failure
2009 36th Annual Computers in Cardiology Conference (CinC), Vol.36, pp.341-344
09/2009
Abstract
Arrhythmias and sudden cardiac death have a circadian pattern of occurrence in humans. We hypothesized that a circadian pattern of arrhythmias is also present in transgenic mice with cardiac-specific overexpression of tumor necrosis factor alpha, which develop a dilated cardiomyopathy, arrhythmias and heart failure. To test this hypothesis, telemetry monitors were implanted and 24 hr, ambulatory ECG was recorded ¿ 5 days later. Animals were maintained on a 12 hr light/dark cycle. The incidence of ventricular arrhythmias increased between 3 pm and 12 am, whereas atrial arrhythmias surged between 4 am and 12 pm. This circadian pattern of arrhythmias is in excellent agreement with human data (taking into account a 12-hour shift between activity periods in diurnal humans and nocturnal rodents). The molecular mechanisms underlying such circadian patterns of arrhythmias were examined using gene expression analysis and mathematical modeling.
Details
- Title: Subtitle
- Circadian pattern to arrhythmias in a genetic mouse model of heart failure
- Creators
- V Shusterman - University of PittsburghC F McTiernan - Univ. of Pittsburgh, Pittsburgh, PA, USAH Mehdi - University of PittsburghW C Troy - Univ. of Pittsburgh, Pittsburgh, PA, USAB London - University of Pittsburgh
- Resource Type
- Conference proceeding
- Publication Details
- 2009 36th Annual Computers in Cardiology Conference (CinC), Vol.36, pp.341-344
- Publisher
- IEEE
- ISSN
- 0276-6574
- eISSN
- 2325-8853
- Language
- English
- Date published
- 09/2009
- Academic Unit
- Cardiovascular Medicine; Internal Medicine; Molecular Physiology and Biophysics
- Record Identifier
- 9984297616002771
Metrics
3 Record Views