Conference proceeding
Classification of pulmonary airway disease based on mucosal color analysis
Proceedings of SPIE, Vol.5746(1), pp.465-473
Medical Imaging 2005: Physiology, Function, and Structure from Medical Images
04/14/2005
DOI: 10.1117/12.595938
Abstract
Airway mucosal color changes occur in response to the development of bronchial diseases including lung cancer, cystic fibrosis, chronic bronchitis, emphysema and asthma. These associated changes are often visualized using standard macro-optical bronchoscopy techniques. A limitation to this form of assessment is that the subtle changes that indicate early stages in disease development may often be missed as a result of this highly subjective assessment, especially in inexperienced bronchoscopists. Tri-chromatic CCD chip bronchoscopes allow for digital color analysis of the pulmonary airway mucosa. This form of analysis may facilitate a greater understanding of airway disease response. A 2-step image classification approach is employed: the first step is to distinguish between healthy and diseased bronchoscope images and the second is to classify the detected abnormal images into 1 of 4 possible disease categories. A database of airway mucosal color constructed from healthy human volunteers is used as a standard against which statistical comparisons are made from mucosa with known apparent airway abnormalities. This approach demonstrates great promise as an effective detection and diagnosis tool to highlight potentially abnormal airway mucosa identifying a region possibly suited to further analysis via airway forceps biopsy, or newly developed micro-optical biopsy strategies. Following the identification of abnormal airway images a neural network is used to distinguish between the different disease classes. We have shown that classification of potentially diseased airway mucosa is possible through comparative color analysis of digital bronchoscope images. The combination of the two strategies appears to increase the classification accuracy in addition to greatly decreasing the computational time.
Details
- Title: Subtitle
- Classification of pulmonary airway disease based on mucosal color analysis
- Creators
- Melissa Suter - University of IowaJoseph M Reinhardt - University of IowaDavid Riker - University of IowaJohn Scott Ferguson - University of IowaGeoffrey McLennan - University of Iowa
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.5746(1), pp.465-473
- Conference
- Medical Imaging 2005: Physiology, Function, and Structure from Medical Images
- DOI
- 10.1117/12.595938
- ISSN
- 0277-786X
- Language
- English
- Date published
- 04/14/2005
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984196974002771
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