Co-55 Separation From Proton Irradiated Metallic Nickel

H. F. Valdovinos; S. Graves; T. Barnhart; R. J. Nickles

doi:10.1063/1.4901397

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Co-55 Separation From Proton Irradiated Metallic Nickel

Conference proceeding

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Co-55 Separation From Proton Irradiated Metallic Nickel

H. F. Valdovinos, S. Graves, T. Barnhart and R. J. Nickles

XIII Mexican Symposium on Medical Physics, Vol.1626, pp.217-220

AIP Conference Proceedings

01/01/2014

DOI: 10.1063/1.4901397

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Abstract

Co-55 with > 97% radionuclidic purity 24 hours after end of bombardment (EoB) was produced from the Ni-58(p,alpha) reaction using proton irradiations of 16 MeV on natural nickel. Two-hour irradiations with 25 mu A on a 254 mu m thick nickel foil generate 0.18 +/- 0.01 GBq (n = 3) 24 hours after EoB. The separation of cobalt from the target material and other metallic contaminants present at trace levels is accomplished in HCl medium by two rounds of anion exchange chromatography (AG1-X8) using an automated module driven by a peristaltic pump. 80 +/- 5 % (n = 3) of the activity generated at EoB is ready for labeling in 0.1 M HCl one hour after the start of separation. Using 99.999% pure Ni, the reactivity (decay corrected to EoB) with the bifunctional chelator (BFC) DOTA was 8.5 GBq/mu mol; enough for radiolabeling BFC conjugated biomolecules at a nmol scale with > 90% yield. Using 99.9% pure Ni the reactivity with DOTA and NOTA was 0.19 +/- 0.09 GBq/mu mol and 2.9 +/- 1.7 GBq/mu mol (n = 2), respectively. Both cobalt complexes showed 100% in vitro stability in PBS and mouse serum over 41 hours at room temperature. MicroPET images of a miniature Derenzo phantom show excellent resolution where rods of 1.5 mm were separated by two times their diameter.

Physical Sciences

Physics

Life Sciences & Biomedicine

Physics, Applied

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Details

Title: Subtitle: Co-55 Separation From Proton Irradiated Metallic Nickel
Creators: H. F. Valdovinos - University of Wisconsin–Madison
S. Graves - University of Wisconsin–Madison
T. Barnhart - University of Wisconsin–Madison
R. J. Nickles - University of Wisconsin–Madison
Contributors: J D BernalAlvarado (Editor)
R GuzmanCabrera (Editor)
M E Brandan (Editor)
Resource Type: Conference proceeding
Publication Details: XIII Mexican Symposium on Medical Physics, Vol.1626, pp.217-220
Series: AIP Conference Proceedings
DOI: 10.1063/1.4901397
ISSN: 0094-243X
eISSN: 1551-7616
Publisher: Amer Inst Physics
Number of pages: 4
Language: English
Date published: 01/01/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
Record Identifier: 9984383889702771

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