Conference proceeding
Comprehensive serial study of dynamic remodeling of atherosclerotic coronary arteries using IVUS
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol.9788, pp.97880Y-97880Y-6
03/29/2016
DOI: 10.1117/12.2217152
Abstract
We present a semi-automated approach to comprehensively examine coronary remodeling over the entire length of intravascular ultrasound (IVUS) imaged vessels. Serial measurements at baseline and 12-month follow-up are analyzed rather than static data obtained at a single time point. Every IVUS pullback is segmented automatically, and then reviewed and algorithmically refined by an expert using a computer-aided just-enough-interaction approach. Subsequently, pairs of serial IVUS pullbacks are registered automatically using 3D graph optimization approach. Based on plaque volume increases or decreases over time, pullback frames are divided into two groups - progression and regression. It is shown that plaque progression rates are positively correlated with percent stenosis (PS) indices (p≪0.01) while plaque regression rates are negatively correlated with percent stenosis indices (p≪0.01). Moreover, for the progression group, adventitia area increases in direct relation with the baseline percent stenosis (p=0.007) when PS is less than 50%. Significance of such a correlation is not observed when percent stenosis exceeds 50%. Conversely, for the regression group, change of adventitia area is relatively constant for percent stenosis <50%; but decreases in direct relation with baseline stenosis (p≪0.01) when stenosis > 50%. This strongly suggests that lipid lowering treatment may effectively suppress plaque progression and accelerate plaque regression, especially for larger values of percent stenosis, and further accelerate the corresponding adventitia-remodeling process.
Details
- Title: Subtitle
- Comprehensive serial study of dynamic remodeling of atherosclerotic coronary arteries using IVUS
- Creators
- Zhi Chen - University of IowaAndreas Wahle - University of IowaLing Zhang - University of IowaTomas Kovarnik - Charles UniversityJohn J Lopez - Loyola University ChicagoMilan Sonka - University of Iowa
- Contributors
- Barjor Gimi (Editor) - Geisel School of Medicine at Dartmouth (United States)Andrzej Krol (Editor) - SUNY Upstate Medical Univ. (United States)
- Resource Type
- Conference proceeding
- Publication Details
- Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol.9788, pp.97880Y-97880Y-6
- DOI
- 10.1117/12.2217152
- ISSN
- 1605-7422
- Publisher
- SPIE
- Language
- English
- Date published
- 03/29/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984186691802771
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