Conference proceeding
Correlation of measures of regional lung ventilation from 4DCT vs. hyperpolarized helium-3 MR
Proceedings of SPIE, Vol.8317(1), pp.83171E-83171E-7
Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
03/22/2012
DOI: 10.1117/12.912793
Abstract
Radiation induced pulmonary diseases can change the tissue material properties of lung parenchyma and the
mechanics of the respiratory system. Recent advances in multi-detector-row CT (MDCT), 4DCT respiratory
gating methods, and image processing techniques enable us to follow and measure those changes noninvasively
during radiation therapy at a regional level. This study compares the 4DCT based ventilation measurement with
the results from hyperpolarized helium-3 MR using the cumulative distribution function maps and the relative
overlap (RO) statistic. We show that the similarity between the two measurements increases as the increase of
the B-Spline grid spacing and Laplacian weighting which result a smoother ventilation map. The best similarity
is found with weighting of 0.5 for linear elasticity and B-Spline grid spacing of 32 mm. Future work is to improve
the lung image registration algorithm by incorporating hyperpolarized helium-3 MR information so as to improve
its physiological modeling of the lung tissue deformation.
Details
- Title: Subtitle
- Correlation of measures of regional lung ventilation from 4DCT vs. hyperpolarized helium-3 MR
- Creators
- Kai Ding - University of VirginiaKunlin Cao - University of IowaWilson Miller - University of VirginiaGary Christensen - University of IowaJoseph Reinhardt - University of IowaStanley Benedict - University of VirginiaBruce Libby - University of VirginiaKe Sheng - University of California, Los Angeles
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.8317(1), pp.83171E-83171E-7
- Conference
- Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
- DOI
- 10.1117/12.912793
- ISSN
- 0277-786X
- Language
- English
- Date published
- 03/22/2012
- Academic Unit
- Electrical and Computer Engineering; Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology; Radiation Research Laboratory; The Iowa Institute for Biomedical Imaging; Advanced Pulmonary Physiomic Imaging Laboratory; Holden Comprehensive Cancer Center
- Record Identifier
- 9984197121802771
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