Conference proceeding
Cortical control of intraspinal microstimulation: Toward a new approach for restoration of function after spinal cord injury
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Vol.2015-, pp.2159-2162
08/2015
DOI: 10.1109/EMBC.2015.7318817
PMID: 26736717
Abstract
Approximately 6 million people in the United States are currently living with paralysis in which 23% of the cases are related to spinal cord injury (SCI). Miniaturized closed-loop neural interfaces have the potential for restoring function and mobility lost to debilitating neural injuries such as SCI by leveraging recent advancements in bioelectronics and a better understanding of the processes that underlie functional and anatomical reorganization in an injured nervous system. This paper describes our current progress toward developing a miniaturized brain-machine-spinal cord interface (BMSI) that converts in real time the neural command signals recorded from the cortical motor regions to electrical stimuli delivered to the spinal cord below the injury level. Using a combination of custom integrated circuit (IC) technology for corticospinal interfacing and field-programmable gate array (FPGA)-based technology for embedded signal processing, we demonstrate proof-of-concept of distinct muscle pattern activation via intraspinal microstimulation (ISMS) controlled in real time by intracortical neural spikes in an anesthetized laboratory rat.
Details
- Title: Subtitle
- Cortical control of intraspinal microstimulation: Toward a new approach for restoration of function after spinal cord injury
- Creators
- Shahab Shahdoost - Electr. Eng. & Comput. Sci. Dept., Case Western Reserve Univ., Cleveland, OH, USAShawn Frost - Med. Center, Mol. & Integrative Physiol. Dept., Univ. of Kansas, Lawrence, KS, USACaleb Dunham - Med. Center, Mol. & Integrative Physiol. Dept., Univ. of Kansas, Lawrence, KS, USAStacey DeJong - Phys. Therapy & Rehabilitation Sci. Dept., Univ. of Iowa, Iowa City, IA, USAScott Barbay - Med. Center, Mol. & Integrative Physiol. Dept., Univ. of Kansas, Lawrence, KS, USARandolph Nudo - Med. Center, Rehabilitation Med. Dept., Univ. of Kansas, Lawrence, KS, USAPedram Mohseni - Electr. Eng. & Comput. Sci. Dept., Case Western Reserve Univ., Cleveland, OH, USA
- Resource Type
- Conference proceeding
- Publication Details
- 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Vol.2015-, pp.2159-2162
- Publisher
- IEEE
- DOI
- 10.1109/EMBC.2015.7318817
- PMID
- 26736717
- ISSN
- 1094-687X
- eISSN
- 1558-4615
- Language
- English
- Date published
- 08/2015
- Academic Unit
- Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984047634402771
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