Conference proceeding
Determining degree of optic nerve edema from color fundus photography
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol.9414, pp.94140F-94140F-9
03/20/2015
DOI: 10.1117/12.2081423
Abstract
Swelling of the optic nerve head (ONH) is subjectively assessed by clinicians using the Frisén scale. It is believed that a direct measurement of the ONH volume would serve as a better representation of the swelling. However, a direct measurement requires optic nerve imaging with spectral domain optical coherence tomography (SD-OCT) and 3D segmentation of the resulting images, which is not always available during clinical evaluation. Furthermore, telemedical imaging of the eye at remote locations is more feasible with non-mydriatic fundus cameras which are less costly than OCT imagers. Therefore, there is a critical need to develop a more quantitative analysis of optic nerve swelling on a continuous scale, similar to SD-OCT. Here, we select features from more commonly available 2D fundus images and use them to predict ONH volume. Twenty-six features were extracted from each of 48 color fundus images. The features include attributes of the blood vessels, optic nerve head, and peripapillary retina areas. These features were used in a regression analysis to predict ONH volume, as computed by a segmentation of the SD-OCT image. The results of the regression analysis yielded a mean square error of 2.43 mm3 and a correlation coefficient between computed and predicted volumes of R = 0:771, which suggests that ONH volume may be predicted from fundus features alone.
Details
- Title: Subtitle
- Determining degree of optic nerve edema from color fundus photography
- Creators
- Jason Agne - The Univ. of Iowa (United States)Jui-Kai Wang - The Univ. of Iowa (United States)Randy H Kardon - Iowa City VA Health Care System (United States)Mona K Garvin - Iowa City VA Health Care System (United States)
- Contributors
- Lubomir M Hadjiiski (Editor) - Univ. of Michigan Health System (United States)Georgia D Tourassi (Editor) - Oak Ridge National Lab. (United States)
- Resource Type
- Conference proceeding
- Publication Details
- Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol.9414, pp.94140F-94140F-9
- Publisher
- SPIE
- DOI
- 10.1117/12.2081423
- ISSN
- 1605-7422
- Language
- English
- Date published
- 03/20/2015
- Academic Unit
- Iowa Neuroscience Institute; Electrical and Computer Engineering; Ophthalmology and Visual Sciences
- Record Identifier
- 9984070703802771
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