Conference proceeding
Effect of early recurrence of hepatitis C on late biliary anastomotic stricture after liver transplantation
Transplantation proceedings, Vol.38(10), pp.3661-3662
World transplant congress 2006, Hynes convention center, Boston, Massachusetts, July 22-27, 2006
2006
DOI: 10.1016/j.transproceed.2006.10.131
PMID: 17175360
Abstract
The aim of the current study was to clarify whether recurrence of hepatitis C (HCV) infection affects biliary complications after liver transplantation (OLT), with special reference to late biliary anastomotic strictures (LBAS). We reviewed 665 consecutive adult OLT recipients with a choledochocholedochostomy without T-tube placement between 1990 and 2005. Biliary anastomotic stricture was confirmed by ERCP. The LBAS was defined as stricture that occurred 30 days or more after OLT. Recurrence of HCV was diagnosed by histological examination using liver biopsy specimen and confirmed by the presence of HCV-RNA. Early HCV recurrence was defined as recurrence that occurred within 6 months after OLT; LBAS occurred in 54 patients (8% of total). Mean duration from OLT to occurrence of LBAS was 6.9 months (1–44 months). Patients with HCV infection had higher occurrence of LBAS than did non-HCV patients (11% vs 5%, P = .0093). Among HCV patients, those with early HCV recurrence had exclusively high rate of LBAS (16%). In multivariate analyses, early recurrence of HCV (P < .001, relative risk [RR] 6.4), as well as occurrence of HAT (P = .0018, RR 8.0), and prolonged CIT (P = .034, RR 3.3) were independent risk factors affecting LBAS. In conclusion, patients with HCV infection have increased occurrence of LBAS after OLT. Additionally, early recurrence of HCV contributes to a higher rate of LBAS.
Details
- Title: Subtitle
- Effect of early recurrence of hepatitis C on late biliary anastomotic stricture after liver transplantation
- Creators
- T FUJIKAWA - Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United StatesS FUJITA - Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United StatesK. L MEKEEL - Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United StatesA. I REED - Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United StatesD. P FOLEY - Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United StatesR. D KIM - Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United StatesR. J HOWARD - Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United StatesA. W HEMMING - Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States
- Resource Type
- Conference proceeding
- Publication Details
- Transplantation proceedings, Vol.38(10), pp.3661-3662
- Conference
- World transplant congress 2006, Hynes convention center, Boston, Massachusetts, July 22-27, 2006
- Publisher
- Elsevier Science; New York, NY
- DOI
- 10.1016/j.transproceed.2006.10.131
- PMID
- 17175360
- ISSN
- 0041-1345
- eISSN
- 1873-2623
- Language
- English
- Date published
- 2006
- Academic Unit
- Accounting; Surgery
- Record Identifier
- 9984051738402771
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