Effects of Physical Activity on Trabecular Bone Micro-Architecture: A Comparative Study in Young Men and Women Using Multi-Detector CT and Volumetric Topological Analysis

Punam K Saha; Yinxiao Liu; Trudy L Burns; James C Torner; Steven M Levy

doi:10.1109/ICBMI.2011.58

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Conference proceeding

Effects of Physical Activity on Trabecular Bone Micro-Architecture: A Comparative Study in Young Men and Women Using Multi-Detector CT and Volumetric Topological Analysis

Punam K Saha, Yinxiao Liu, Trudy L Burns, James C Torner and Steven M Levy

2011 International Conference on Intelligent Computation and Bio-Medical Instrumentation, pp.283-286

12/2011

DOI: 10.1109/ICBMI.2011.58

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Abstract

Adult bone diseases, especially osteoporosis, increase risk of fracture associated with substantial morbidity, mortality, and financial costs. Osteoporosis is clinically defined by low bone mineral density (BMD). However, increasing evidence suggests that trabecular bone (TB) micro-architectural quality is an important determinant of bone strength and fracture risk. Recently, a volumetric topological analysis (VTA) method has been developed and a peripheral high resolution multi-detector CT (MDCT) bone imaging protocol has been established in our laboratory, resulting in enhanced quantitative 3-D TB micro-architectural assessment. At each TB location, the method uniquely classifies local topology on the continuum between a perfect plate and a perfect rod, facilitating early detection of bone alteration. Here, we present our experimental results evaluating the feasibility of the method for in vivo assessment of TB micro-architecture in young women and men. Also, the method's ability to detect physical activity effects on TB micro-architecture is examined.

Biomechanics

Computed Tomography

Osteoporosis

Topology

Bones

CT imaging

digital topology

Manifolds

quantitative morphometry

Trabecular bone

Volume measurement

Details

Title: Subtitle: Effects of Physical Activity on Trabecular Bone Micro-Architecture: A Comparative Study in Young Men and Women Using Multi-Detector CT and Volumetric Topological Analysis
Creators: Punam K Saha - University of Iowa
Yinxiao Liu - University of Iowa
Trudy L Burns - University of Iowa
James C Torner - University of Iowa
Steven M Levy - University of Iowa
Resource Type: Conference proceeding
Publication Details: 2011 International Conference on Intelligent Computation and Bio-Medical Instrumentation, pp.283-286
DOI: 10.1109/ICBMI.2011.58
Publisher: IEEE
Language: English
Date published: 12/2011
Academic Unit: Preventive and Community Dentistry; Neurology; Radiology; Electrical and Computer Engineering; Epidemiology; Surgery; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9984197277202771

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