Conference proceeding
Endothelial mechanotransduction, nitric oxide and vascular inflammation
Journal of internal medicine, Vol.259(4), pp.351-363
Mechanotransduction and translational medicine workshop
2006
DOI: 10.1111/j.1365-2796.2006.01621.x
PMID: 16594903
Abstract
Numerous aspects of vascular homeostasis are modulated by nitric oxide and reactive oxygen species (ROS). The production of these is dramatically influenced by mechanical forces imposed on the endothelium and vascular smooth muscle. In this review, we will discuss the effects of mechanical forces on the expression of the endothelial cell nitric oxide synthase, production of ROS and modulation of endothelial cell glutathione. We will also review data that exercise training in vivo has a similar effect as laminar shear on endothelial function and discuss the clinical relevance of these basic findings.
Details
- Title: Subtitle
- Endothelial mechanotransduction, nitric oxide and vascular inflammation
- Creators
- D. G HARRISON - Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United StatesJ WIDDER - Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United StatesI GRUMBACH - Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United StatesW CHEN - Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United StatesM WEBER - Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United StatesC SEARLES - Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States
- Resource Type
- Conference proceeding
- Publication Details
- Journal of internal medicine, Vol.259(4), pp.351-363
- Conference
- Mechanotransduction and translational medicine workshop
- Publisher
- Blackwell Science
- DOI
- 10.1111/j.1365-2796.2006.01621.x
- PMID
- 16594903
- ISSN
- 0954-6820
- eISSN
- 1365-2796
- Language
- English
- Date published
- 2006
- Academic Unit
- Cardiovascular Medicine; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984094369602771
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