Conference proceeding
Estimating the actual dose delivered by intravascular coronary brachytherapy using geometrically correct 3D modeling
Proceedings of SPIE, Vol.5029(1), pp.129-137
Medical Imaging 2003: Visualization, Image-Guided Procedures, and Display
05/30/2003
DOI: 10.1117/12.480218
Abstract
Intravascular brachytherapy has shown to reduce re-occurrence of in-stent restenosis in coronary arteries. For beta radiation, application time is determined from source activity and the angiographically estimated vessel diameter. Conventionally used dosing models assume a straight vessel with the catheter centered and a constant-diameter circular cross section. Aim of this study was to compare the actual dose delivered during in-vivo intravascular brachytherapy with the target range determined from the patient's prescribed dose. Furthermore, differences in dose distribution between a simplified tubular model (STM) and a geometrically correct 3-D model (GCM) obtained from fusion between biplane angiography and intravascular ultrasound were quantified. The tissue enclosed by the segmented lumen/plaque and media/adventitia borders was simulated using a structured finite-element mesh. The beta-radiation sources were modeled as 3-D objects in their angiographically determined locations. The accumulated dose was estimated using a fixed distance function based on the patient-specific radiation parameters. For visualization, the data was converted to VRML with the accumulated doses represented by color encoding. The statistical comparison between STM and GCM models in 8 patients showed that the STM significantly underestimates the dose delivered and its variability. The analysis revealed substantial deviations from the target dose range in curved vessels.
Details
- Title: Subtitle
- Estimating the actual dose delivered by intravascular coronary brachytherapy using geometrically correct 3D modeling
- Creators
- Andreas Wahle - Univ. of Iowa (USA)John J Lopez - Univ. of Iowa (USA) and Univ. of Chicago (USA)Edward C Pennington - Univ. of Iowa (USA)Sanford L Meeks - Univ. of Iowa (USA)Kathleen C Braddy - Univ. of Iowa (USA)James M Fox - Univ. of Iowa (USA)Theresa M. H Brennan - Univ. of Iowa (USA)John M Buatti - Univ. of Iowa (USA)James D Rossen - Univ. of Iowa (USA)Milan Sonka - Univ. of Iowa (USA)
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.5029(1), pp.129-137
- Conference
- Medical Imaging 2003: Visualization, Image-Guided Procedures, and Display
- DOI
- 10.1117/12.480218
- ISSN
- 0277-786X
- Language
- English
- Date published
- 05/30/2003
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Electrical and Computer Engineering; Cardiovascular Medicine; Radiation Oncology; Injury Prevention Research Center; Neurosurgery; Otolaryngology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984047705202771
Metrics
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