Conference proceeding
Fibroblast-Mediated Fiber Realignment in Fibrin Gels
Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, Vol.1
ASME 2013 Summer Bioengineering Conference, Sunriver, Oregon, USA, Jun. 26 - 29, 2013
06/26/2013
DOI: 10.1115/SBC2013-14385
Abstract
When fibroblasts are added to a fibrin gel, the cells rapidly compact the gel and produce a fiber alignment pattern that depends in part on the cell traction forces, gel geometry, and gel mechanical constraints [1]. Over time the fibrin is digested and replaced with cell synthesized collagen and other extracellular matrix (ECM) proteins that follow the initial alignment pattern of the gel [2]. This remodeling process proceeds in a complex and integrated manner that is influenced by the mechanical environment [3]. In order to better understand fibroblast-fibrin interactions and the remodeling process, we obtained time-lapse images of the development of fiber alignment between clusters of dermal fibroblasts (i.e., explants) in a fibrin gel. The experimental results were then compared to a model that incorporated the effects of traction forces on ECM reorganization.
Details
- Title: Subtitle
- Fibroblast-Mediated Fiber Realignment in Fibrin Gels
- Creators
- Aribet M De Jesus - University of IowaMaziar Aghvami - University of IowaEdward A Sander - University of Iowa
- Resource Type
- Conference proceeding
- Publication Details
- Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, Vol.1
- Conference
- ASME 2013 Summer Bioengineering Conference, Sunriver, Oregon, USA, Jun. 26 - 29, 2013
- DOI
- 10.1115/SBC2013-14385
- Publisher
- American Society of Mechanical Engineers
- Language
- English
- Date published
- 06/26/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
- Record Identifier
- 9984185470202771
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