Fluid mechanics and mass transport analysis in stenosed carotid arteries

Y T Liu; H Udaykumar; A Nagaraj; A Hamilton; D D McPherson; K B Chandran

doi:10.1109/IEMBS.2002.1106402

Back

Conference proceeding

Fluid mechanics and mass transport analysis in stenosed carotid arteries

Y T Liu, H Udaykumar, A Nagaraj, A Hamilton, D D McPherson and K B Chandran

SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS: BIOENGINEERING - INTEGRATIVE METHODOLOGIES, NEW TECHNOLOGIES, pp.1309-1310

2002

DOI: 10.1109/IEMBS.2002.1106402

View Online

Abstract

The fluid dynamics distal to a stenosis in vivo, and its effect on mass transport of LDL and oxygen were analyzed through a computational simulation. The in vivo carotid artery stenosis was created by denuding the arterial intinial surface in a Yucatan miniswine atheroma model. The animals were then fed high cholesterol diet. After 8 weeks, images of the atheroma forming arterial segments were obtained using intravascular ultrasound (IVUS) and reconstructed into a three-dimensional mesh. The computational model included unsteady flow analysis with time varying inflow velocity and with the measured distensibility specified as boundary conditions, as well as LDL and oxygen transport analysis. The results indicated flow separation and reattachment distal to the stenosis. Mean:wall shear stress was the highest at the stenosis-throat and became negative at the flow re-circulation zone. the high wall shear stress regions LDL accumulation was reduced while oxygen transport was increased. In the low wall shear regions, the reduced arterial flows enhanced LDL accumulation but at the same time decreased the oxygen concentration. The analysis indicated that regions distal to the stenosis with oxygen deprivation and enhanced LDL accumulation in low wall shear regions may result in further growth of atheroma.

Details

Title: Subtitle: Fluid mechanics and mass transport analysis in stenosed carotid arteries
Creators: Y T Liu
H Udaykumar
A Nagaraj
A Hamilton
D D McPherson
K B Chandran
Resource Type: Conference proceeding
Publication Details: SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS: BIOENGINEERING - INTEGRATIVE METHODOLOGIES, NEW TECHNOLOGIES, pp.1309-1310
DOI: 10.1109/IEMBS.2002.1106402
Language: English
Date published: 2002
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Injury Prevention Research Center; Mechanical Engineering
Record Identifier: 9984230118202771

Metrics

9 Record Views

See more details