Conference proceeding
GABAergic control of backpropagating action potentials in striatal medium spiny neurons
BMC Neuroscience, Vol.9(S1), pp.P105-P105
07/11/2008
DOI: 10.1186/1471-2202-9-S1-P105
Abstract
Experiments have demonstrated the ability of action potentials to actively backpropagate in striatal medium spiny (MS) neurons, affecting the calcium levels in the dendrites[1-3]. Increased calcium levels trigger changes in plasticity[4,5], which is important for learning and other functions[6]. Studies in the hippocampus have shown that GABAergic input can modulate the backpropagation of action potentials from the soma to the distal dendrites[7]. The MS neurons receive both proximal feedforward GABAergic inhibition from fast spiking interneurons (FS), and distal feedback inhibition from other neighbouring MS neurons. In the present study the effect of these GABAergic inputs on the dendritic calcium dynamics is investigated.
Details
- Title: Subtitle
- GABAergic control of backpropagating action potentials in striatal medium spiny neurons
- Creators
- Johannes Hjorth - AlbaNovaM Zilberter - Karolinska InstitutetR.F. OliveriaKim T. Blackwell - George Mason UniversityJeanette Hellgren Kotaleski - Beräkningsbiologi, CB
- Resource Type
- Conference proceeding
- Publication Details
- BMC Neuroscience, Vol.9(S1), pp.P105-P105
- DOI
- 10.1186/1471-2202-9-S1-P105
- ISSN
- 1471-2202
- eISSN
- 1471-2202
- Language
- English
- Date published
- 07/11/2008
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984446711802771
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