Conference proceeding
GABAergic control of dendritic calcium dynamics in striatal medium spiny neurons
Frontiers in neuroinformatics, Vol.2
2008
DOI: 10.3389/conf.neuro.11.2008.01.044
Abstract
Experiments have demonstrated the ability of action potentials to actively backpropagate in striatal medium spiny (MS) neurons, affecting the calcium levels in the dendrites [1, 2, 3]. Increased calcium levels trigger changes in plasticity [4, 5], which is important for learning and other functions [6]. Studies in the hippocampus have shown that GABAergic input can modulate the backpropagation of action potentials from the soma to the distal dendrites [7]. The MS neurons receive both proximal feedforward GABAergic inhibition from fast spiking interneurons (FS), and distal feedback inhibition from other neighbouring MS neurons. In the present study the effect of GABAergic inputs on the dendritic calcium dynamics is investigated.
Details
- Title: Subtitle
- GABAergic control of dendritic calcium dynamics in striatal medium spiny neurons
- Creators
- Johannes HjorthP KriegerR.F. OliveiraKim T BlackwellJeanette Hellgren Kotaleski - Beräkningsbiologi, CB
- Resource Type
- Conference proceeding
- Publication Details
- Frontiers in neuroinformatics, Vol.2
- DOI
- 10.3389/conf.neuro.11.2008.01.044
- ISSN
- 1662-5196
- eISSN
- 1662-5196
- Language
- English
- Date published
- 2008
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984447837202771
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