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Generalized Anisotropic Inverse Mechanics: Mechanical Anisotropy Correlates With Structural Anisotropy in Collagen Based Tissue Equivalents
Conference proceeding

Generalized Anisotropic Inverse Mechanics: Mechanical Anisotropy Correlates With Structural Anisotropy in Collagen Based Tissue Equivalents

Ramesh Raghupathy, Spencer P Lake, Edward A Sander and Victor H Barocas
ASME 2010 Summer Bioengineering Conference, Parts A and B, pp.897-898
ASME 2010 Summer Bioengineering Conference, Naples, Florida, USA, Jun. 16 - 19, 2010
06/16/2010
DOI: 10.1115/SBC2010-19215

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Abstract

Few elastographic methods handle both anisotropy and inhomogeneity. Much of the focus has been on inhomogeneous materials that are locally isotropic. However, most load-bearing tissues (heart, ligament, blood vessels) are highly anisotropic, and the underlying structure is distinct and essential for function. With disease or damage, this structure is altered, and hence the potential for an elastographic tool that identifies regional changes in anisotropy is high. In this study we present a generalized anisotropic inverse mechanics (GAIM) method that is applicable to soft tissues and demonstrate its performance on tissue equivalents which serve as a convenient test case due to their inhomogeneity and the ease of pre-specifying the fiber alignment pattern.

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