Conference proceeding
Herbal Supplement-Based Interactions
ENZYME- AND TRANSPORTER-BASED DRUG-DRUG INTERACTIONS: PROGRESS AND FUTURE CHALLENGES, pp.555-584
01/01/2010
DOI: 10.1007/978-1-4419-0840-7_22
Abstract
As herbal supplements are purchased and used by more than 25% of the general population, herbal supplement-based interactions have become increasingly reported. The primary mechanism of herb drug interactions is modulation of metabolizing enzymes and/or transporters. This chapter highlights the modulation effects of several top selling herbal supplements (St. John's wort, garlic, ginseng, milk thistle, ginkgo, and others) and important herbal constituents (flavonoids and isothiocyanates) on metabolizing enzymes/transporters and the subsequent herb-drug interactions. Literature reports indicate that these herbal supplements/constituents modulate various phase I/II enzymes and/or transporters at both functional and expression levels and have an impact on the pharmacokinetics of co-administered drugs, which are mainly metabolized/transported by these enzymes/transporters. The alteration in enzyme/transporter function by an herbal product may vary markedly due to different manufacturers or lots of herbal products, doses, drug substrates, and experimental systems used to evaluate potential interactions. Many effects of herbal supplements/constituents on enzymes/transporters have been investigated only in vitro. Further in vivo animal studies and clinical trials need to be carried out to confirm these in vitro observations and determine the clinical relevance of herbal-drug interactions.
Details
- Title: Subtitle
- Herbal Supplement-Based Interactions
- Creators
- Guohua An - State University of New YorkMarilyn E. Morris - State University of New York
- Contributors
- K S Pang (Editor)A D Rodrigues (Editor)R M Peter (Editor)
- Resource Type
- Conference proceeding
- Publication Details
- ENZYME- AND TRANSPORTER-BASED DRUG-DRUG INTERACTIONS: PROGRESS AND FUTURE CHALLENGES, pp.555-584
- Publisher
- Amer Assoc Pharmaceutical Scientists
- DOI
- 10.1007/978-1-4419-0840-7_22
- Number of pages
- 30
- Grant note
- BCTR138506 / Susan G. Komen Foundation; Susan G. Komen Breast Cancer Foundation R01DA023223; R03CA121404 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 01/01/2010
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984365902502771
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