Conference proceeding
Image-based multiscale structural models of fibrous engineered tissues
Conference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.), Vol.2009, pp.4270-4272
2009
DOI: 10.1109/IEMBS.2009.5334586
PMID: 19965027
Abstract
While it is firmly established that the mechanical behavior of most biological tissues, including bioengineered tissues, is governed by an underlying network of protein fibers, it is still not clear how best to obtain and utilize structural information to predict mechanical response. In this paper, methods are presented to (1) quantify the fiber arrangement in a tissue from different imaging tools, (2) incorporate that structure into a multiscale model, and (3) solve the model equations to predict both the microscopic and the macroscopic tissue response. In principle these concepts could be applied to any tissue (incorporating the specific tissue components as needed), but for demonstration purposes, the focus of the current work is on cell-compacted collagen gel, a model engineered tissue.
Details
- Title: Subtitle
- Image-based multiscale structural models of fibrous engineered tissues
- Creators
- Edward A Sander - University of MinnesotaRobert T Tranquillo - University of MinnesotaVictor H Barocas - University of Minnesota
- Resource Type
- Conference proceeding
- Publication Details
- Conference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.), Vol.2009, pp.4270-4272
- DOI
- 10.1109/IEMBS.2009.5334586
- PMID
- 19965027
- NLM abbreviation
- Conf Proc IEEE Eng Med Biol Soc
- eISBN
- 9781424432967; 1424432960
- ISSN
- 1557-170X
- eISSN
- 1558-4615
- Grant note
- R01 EB005813 / NIBIB NIH HHS F32 EB007433 / NIBIB NIH HHS
- Language
- English
- Date published
- 2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
- Record Identifier
- 9984197118302771
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