Impact of cerebral edema on diffuse optical spectroscopy quantification during extracorporeal membrane oxygenation (ECMO)

Jharna Jahnavi; Jonathan Starr; Kristen N. Andersen; Jake Breimann; Emilie J. Benson; Jonah A. Padawer-Curry; Tim Benson; Giselle Matlis; Alec Lafontant; Thomas Hallowell; William P. Landis; Yuxi Lin; Nile Delso; Anna L. Roberts; Kathryn Graham; Julia C. Slovis; Lindsay E. Volk; Richard W Melchior; Ryan W. Morgan; Brian R. White; Arjun G. Yodh; Marco M. Hefti; Daniel J. Licht; Todd J. Kilbaugh; Wesley B. Baker; Tiffany Ko

doi:10.1117/12.2578917

Conference proceeding

Impact of cerebral edema on diffuse optical spectroscopy quantification during extracorporeal membrane oxygenation (ECMO)

Jharna Jahnavi, Jonathan Starr, Kristen N. Andersen, Jake Breimann, Emilie J. Benson, Jonah A. Padawer-Curry, Tim Benson, Giselle Matlis, Alec Lafontant, Thomas Hallowell, …

Optical Tomography and Spectroscopy of Tissue XIV

03/05/2021

DOI: 10.1117/12.2578917

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Abstract

Extracorporeal membrane oxygenation (ECMO) is an important therapy for critically ill children but survivors have neurodevelopmental impairments. Cerebral inflammatory response resulting in brain edema is observed on ECMO. This pathologic response may adversely impact the quantitative accuracy of diffuse optical spectroscopy (DOS) neuromonitoring (including commercial NIRS) which commonly assumes a 75% water fraction. Using fresh brain tissue desiccation, we directly quantified the severity of cerebral edema in pediatric swine following cardiac arrest, CPR and 22-24 hours of ECMO therapy. The fractional error in DOS quantification of cerebral hemodynamics from assuming 75% water fraction was determined to be <5%.

Cardiology

Internal Medicine

Brain edema

Brain tissue

Cerebral edema

Cerebral hemodynamics

Critically ill

Extracorporeal membrane oxygenation

Inflammatory response

Quantitative accuracy

surgical procedures, operative

Details

Title: Subtitle: Impact of cerebral edema on diffuse optical spectroscopy quantification during extracorporeal membrane oxygenation (ECMO)
Creators: Jharna Jahnavi - Children's Hospital of Philadelphia
Jonathan Starr - Children's Hospital of Philadelphia
Kristen N. Andersen - Children's Hospital of Philadelphia
Jake Breimann - Children's Hospital of Philadelphia
Emilie J. Benson - Children's Hospital of Philadelphia
Jonah A. Padawer-Curry - Children's Hospital of Philadelphia
Tim Benson - Children's Hospital of Philadelphia
Giselle Matlis - Children's Hospital of Philadelphia
Alec Lafontant - Children's Hospital of Philadelphia
Thomas Hallowell - Children's Hospital of Philadelphia
William P. Landis - Children's Hospital of Philadelphia
Yuxi Lin - Children's Hospital of Philadelphia
Nile Delso - Children's Hospital of Philadelphia
Anna L. Roberts - Children's Hospital of Philadelphia
Kathryn Graham - Children's Hospital of Philadelphia
Julia C. Slovis - Children's Hospital of Philadelphia
Lindsay E. Volk - Children's Hospital of Philadelphia
Richard W Melchior - Children's Hospital of Philadelphia
Ryan W. Morgan - Children's Hospital of Philadelphia
Brian R. White - Children's Hospital of Philadelphia
Arjun G. Yodh - University of Pennsylvania
Marco M. Hefti - University of Iowa
Daniel J. Licht - Children's Hospital of Philadelphia
Todd J. Kilbaugh - Children's Hospital of Philadelphia
Wesley B. Baker - Children's Hospital of Philadelphia
Tiffany Ko - Children's Hospital of Philadelphia
Resource Type: Conference proceeding
Publication Details: Optical Tomography and Spectroscopy of Tissue XIV
Publisher: SPIE
DOI: 10.1117/12.2578917
Language: English
Date published: 03/05/2021
Academic Unit: Pathology; Iowa Neuroscience Institute
Record Identifier: 9984530267602771

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