Improvement of free fat graft survival: In vivo long-term delivery of IGF and insulin using PLGA/PEG microspheres

A Weinfeld; E Yuksel; S Wamsley; J Jensen; B S Boutros; R Cleek; A Mikos; S Shenaq; M Spira

doi:10.1109/SBEC.1998.666631

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Conference proceeding

Improvement of free fat graft survival: In vivo long-term delivery of IGF and insulin using PLGA/PEG microspheres

A Weinfeld, E Yuksel, S Wamsley, J Jensen, B S Boutros, R Cleek, A Mikos, S Shenaq and M Spira

Proceedings of the 17th Southern Biomedical Engineering Conference, 6-8 Feb. 1998, pp.37-37

01/01/1998

DOI: 10.1109/SBEC.1998.666631

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Abstract

The effect of the long term delivery polylactic glycolic acid /polyethylene glycol (PLGA/PEG) microspheres of the adipogenic growth factors on fat graft survival rates is described. PLGA/PEG microspheres incorporated with insulin and interleukin growth factor (IGF), separately, are manufactured using a double-emulsion-solvent extraction technique. The long term delivery of adipogenic growth factors with PLGA/PEG microspheres increases fat graft survival rates. The type of growth factor delivered can influence the grafted tissue's relative adipocyte predominance. The drug delivery device has the potential to increase the power, and the versatility, of autologous fat grafting in the clinical arena.

Insulin

Grafting (chemical)

Grafts

Organic acids

Polyethylene glycols

Solvent extraction

Tissue

Details

Title: Subtitle: Improvement of free fat graft survival: In vivo long-term delivery of IGF and insulin using PLGA/PEG microspheres
Creators: A Weinfeld
E Yuksel
S Wamsley
J Jensen
B S Boutros
R Cleek
A Mikos
S Shenaq
M Spira
Resource Type: Conference proceeding
Publication Details: Proceedings of the 17th Southern Biomedical Engineering Conference, 6-8 Feb. 1998, pp.37-37
DOI: 10.1109/SBEC.1998.666631
Language: English
Date published: 01/01/1998
Academic Unit: Surgery
Record Identifier: 9984701549402771

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