Conference proceeding
In vivo tomographic imaging based on bioluminescence
Proceedings of SPIE, Vol.5535(1), pp.212-219
Developments in X-Ray Tomography IV
10/26/2004
DOI: 10.1117/12.560522
Abstract
The most important task for bioluminescence imaging is to identify the emission source from the captured bioluminescent signal on the surface of a small tested animal. Quantitative information on the source location, geometry and intensity serves for in-vivo monitoring of infectious diseases, tumor growth, metastases in the small animal. In this paper, we present a point-spread function-based method for reconstructing the internal bioluminescent source from the surface light output flux signal. The method is evaluated for sensing the internal emission sources in nylon phantoms and within a live mouse. The surface bioluminescent signal is taken with a highly sensitive CCD camera. The results show the feasibility and efficiency of the proposed point-spread function-based method.
Details
- Title: Subtitle
- In vivo tomographic imaging based on bioluminescence
- Creators
- Wenxiang Cong - Univ. of Iowa (USA)Durairaj Kumar - Univ. of Iowa (USA)Yubin Kang - Univ. of Iowa (USA)Patrick Sinn - Univ. of Iowa (USA)Earl Nixon - Univ. of Iowa (USA)John Mienel Jr - Univ. of Iowa (USA)Melissa J Suter - Univ. of Iowa (USA)Lihong V Wang - Texas A&M Univ. (USA)Geoffrey McLennan - Univ. of Iowa (USA)Eric A Hoffman - Univ. of Iowa (USA)Ge Wang - Univ. of Iowa (USA)
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.5535(1), pp.212-219
- Conference
- Developments in X-Ray Tomography IV
- DOI
- 10.1117/12.560522
- ISSN
- 0277-786X
- Language
- English
- Date published
- 10/26/2004
- Academic Unit
- Radiology; Radiation Oncology; Internal Medicine; Roy J. Carver Department of Biomedical Engineering; Microbiology and Immunology; Stead Family Department of Pediatrics; Pulmonary Medicine
- Record Identifier
- 9984046913102771
Metrics
8 Record Views