Conference proceeding
Loss of Contact-Dependent Inhibition of Growth in Chemically Transformed Fibroblasts
Lectins and Glycoconjugates in Oncology, pp.187-197
1988
DOI: 10.1007/978-3-642-73662-9_17
Abstract
The plasma membrane has been recognized as an important regulatory unit of mammalian cells during determination, differentiation, and social behaviour of individual cells within various tissues (1–4). On the molecular level, plasma membrane glycoproteins and glycolipids have been shown to be involved in these processes (1–4). Density-dependent growth of non-transformed cells in vitro has been proposed to be regulated by secreted inhibitory compounds (5–7), by the cell’s shape (8) or by diffusion boundary layers (9). On the other hand, specific cell-cell interactions via cell membrane molecules were found to be of great importance for the contact-dependent inhibition of growth (10–16) and consequently, to be responsible for the stop of growth of non-transformed cells when a confluent monolayer has been established. Several reports have shown the involvement of glycoconjugates in the control of proliferation by indirect means (11, 14, 17–19). Beyond it, a correlation between altered plasma membrane glycosylation and transformation has been demonstrated by numerous studies (20–22), and has been confirmed by DNA-transfection recently (23, 24). Furthermore, inhibitors of glycoprotein processing enzymes led to the loss of transformed phenotype of transformed fibroblasts (25, 26). These results suggest a causal relationship between glycoprotein structures and tumorigenesis.
Details
- Title: Subtitle
- Loss of Contact-Dependent Inhibition of Growth in Chemically Transformed Fibroblasts
- Creators
- B Janik-SchmittF OeschG LudewigR. J Wieser
- Resource Type
- Conference proceeding
- Publication Details
- Lectins and Glycoconjugates in Oncology, pp.187-197
- DOI
- 10.1007/978-3-642-73662-9_17
- Publisher
- Springer Berlin Heidelberg; Berlin, Heidelberg
- Language
- English
- Date published
- 1988
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984214809602771
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