Conference proceeding
MRI-based active shape model of the human proximal femur using fiducial and secondary landmarks and its validation
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol.10578, pp.105781L-105781L-12
03/12/2018
DOI: 10.1117/12.2293732
Abstract
Osteoporosis, associated with reduced bone mineral density and structural degeneration, greatly increases the risk of fragility fracture. A major challenge of volumetric bone imaging of the hip is the selection of regions of interest (ROIs) for computation of regional bone measurements. Here, we develop an MRI-based active shape model (ASM) of the human proximal femur used to automatically generate ROIs. Major challenges in developing the ASM of a complex three-dimensional (3-D) shape lie in determining a large number of anatomically consistent landmarks for a set of training shapes. In this paper, we develop a new method of generating the proximal femur ASM, where two types of landmarks, namely fiducial and secondary landmarks, are used. The method of computing the MRI-based proximal femur ASM consists of—(1) segmentation of the proximal femur bone volume, (2) smoothing the bone surface, (3) drawing fiducial landmark lines on training shapes, (4) drawing secondary landmarks on a reference shape, (5) landmark mesh generation on the reference shape using both fiducial and secondary landmarks, (6) generation of secondary landmarks on other training shapes using the correspondence of fiducial landmarks and an elastic deformation of the landmark mesh, (7) computation of the active shape model. An MRI-based shape model of the human proximalfemur has been developed using hip MR scans of 45 post-menopausal women. The results of secondary landmark generation were visually satisfactory and no topology violation or notable geometric distortion artifacts were observed. Performance of the method was examined in terms of shape representation errors in a leave-one-out test. The mean and standard deviation of leave-one-out shape representation errors were 2.27 and 0.61 voxels respectively. The experimental results suggest that the framework of fiducial and secondary landmark allows reliable computation statistical shape models for complex 3-D anatomic structures.
Details
- Title: Subtitle
- MRI-based active shape model of the human proximal femur using fiducial and secondary landmarks and its validation
- Creators
- Xiaoliu Zhang - University of IowaCheng Chen - University of IowaSean Boone - New York UniversityVivek Joshi - New York UniversityArakua Welbeck - New York UniversityGuoyuan Liang - University of IowaGregory Chang - New York UniversityPunam K Saha - University of Iowa
- Contributors
- Barjor Gimi (Editor) - Rowan UniversityAndrzej Krol (Editor) - SUNY Upstate Medical University
- Resource Type
- Conference proceeding
- Publication Details
- Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol.10578, pp.105781L-105781L-12
- Publisher
- SPIE
- DOI
- 10.1117/12.2293732
- ISSN
- 1605-7422
- Language
- English
- Date published
- 03/12/2018
- Academic Unit
- Electrical and Computer Engineering; Radiology
- Record Identifier
- 9984197553002771
Metrics
7 Record Views