Conference proceeding
Measurement of Mucociliary Transport: Novel Application of Positron Emission Tomography
2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI), pp.1-5
03/28/2022
DOI: 10.1109/ISBI52829.2022.9761605
Abstract
Mucociliary transport (MCT) is an innate defense mechanism of the lungs. Failure of this defense is implicated in several airway diseases. Previous methods to measure MCT in vivo either lack temporal resolution to capture its full dynamics or utilize large particle sizes. The goal of this study is to develop a measurement assay that accurately quantitates MCT, while meeting physiologic characteristics. Positron emission tomography (PET) has been used to capture in vivo dynamic biological processes, such as myocardial blood flow. We hypothesize a PET-based dynamic imaging method will capture MCT within the airways. In a pilot study, physiologically relevant inert radiotracer particles were distally delivered to newborn porcine airways, and an analysis platform was constructed to measure its transport and clearance overtime. PET imaging measurements of dynamic mucus transport and clearance throughout the airways was measured continuously for 15 minutes with a timing resolution of 10 seconds. The fine temporal resolution of dynamic PET captured the clearance and transport of delivered radiolabeled particles overtime.
Details
- Title: Subtitle
- Measurement of Mucociliary Transport: Novel Application of Positron Emission Tomography
- Creators
- Carley G Stewart - University of Iowa,Biomedical Engineering, Roy J. & Lucille A. Carver College of Medicine,Iowa City,IABrieanna Hilkin - University of IowaNicholas D Gansemer - University of IowaSusan A Walsh - University of IowaMichael R Acevado - University of Iowa,Radiology, Roy J. & Lucille A. Carver College of Medicine,Iowa City,IAVamsidhar Akurathi - University of Iowa,Radiology, Roy J. & Lucille A. Carver College of Medicine,Iowa City,IADarpan N Pandya - University of IowaAlejandro F Comellas - University of IowaThaddeus J Wadas - University of IowaDavid W Dick - University of IowaJohn J Sunderland - University of IowaDavid A Stoltz - University of IowaMichael J Welsh - University of IowaMahmoud H Abou Alaiwa - University of Iowa
- Resource Type
- Conference proceeding
- Publication Details
- 2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI), pp.1-5
- DOI
- 10.1109/ISBI52829.2022.9761605
- eISSN
- 1945-8452
- Publisher
- IEEE
- Grant note
- University of Iowa (10.13039/100008893) Howard Hughes Medical Institute (10.13039/100000011)
- Language
- English
- Date published
- 03/28/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; ICTS; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
- Record Identifier
- 9984259442602771
Metrics
75 Record Views