Muscatine Ponderosity Family Study

T.L Burns; P Moll; R.M Lauer

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Conference proceeding

Muscatine Ponderosity Family Study

T.L Burns, P Moll and R.M Lauer

Molecular and genetic aspects of obesity, pp.482-495

1996

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Abstract

A family study was conducted in Muscatine, Iowa, to examine the risk of cardiovascular disease in adult relatives of children with different patterns of ponderosity (body weight relative to height), and to estimate the genetic contribution to familial clustering of levels of ponderosity. Four groups of probands were selected from students who participated in three consecutive biennial school surveys: a random group (n = 70); a lean group (n = 72); a gain group (n = 70); and a heavy group (n = 72). The parents, siblings, a related aunt or uncle, and a first cousin of these probands were examined. Death certificates were obtained for deceased adult relatives. The relative risk of dying from cardiovascular disease for the heavy group versus the random group relatives was 1.41 (95% confidence interval 1.01, 1.98). Complex segregation analysis indicated strong support for a single recessive locus with a major effect that accounted for almost 35% of the age-gender-adjusted variability in body mass index. Genotypic probabilities were assigned to family members, and the effect of the recessive major locus on other measures of body habitus and cardiovascular risk factors was examined. This analysis suggested that individuals whose obesity may be caused by a gene at a single genetic locus are at higher cardiovascular risk because of mechanisms associated with their risk factor profile. We are currently searching for genetic factors responsible for the variability in body mass index. This may lead to early identification of individuals and families at high risk for the development of the chronic diseases associated with obesity.

age differences

aunts

blood lipids

blood pressure

body mass index

body measurements

body weight

boys

cardiovascular diseases

children

cholesterol

cousins

epidemiological studies

estimation

familial incidence

families

gender differences

genes

genetic factors

genetic techniques and protocols

genotype

girls

grandparents

height

high density lipoprotein

indexes

low density lipoprotein

men

mortality

parents

probability analysis

ratios

risk factors

segregation

siblings

skinfold thickness

triacylglycerols

uncles

women

Details

Title: Subtitle: Muscatine Ponderosity Family Study
Creators: T.L Burns
P Moll
R.M Lauer
Resource Type: Conference proceeding
Publication Details: Molecular and genetic aspects of obesity, pp.482-495
Publisher: Baton Rouge : Louisiana State University Press, c1996
Language: English
Date published: 1996
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984364385902771

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