Conference proceeding
Nanoscale optical biosensors based on localized surface plasmon resonance spectroscopy
Proceedings of SPIE, Vol.5221(1), pp.47-58
Plasmonics: Metallic Nanostructures and Their Optical Properties
11/03/2003
DOI: 10.1117/12.508308
Abstract
The Ag nanoparticle based localized surface plasmon resonance (LSPR) nanosensor yields ultrasensitive biodetection with extremely simple, small, light, robust, and low-cost instrumentation. Using LSPR spectroscopy, the model system, biotinylated surface-confined Ag nanotriangles, was used to detect less than one picomolar up to micromolar concentrations of streptavidin. Additionally, the monitoring of anti-biotin binding to biotinylated Ag nanotriangles exhibited that the system could be used as a solution immunoassay. The system was rigorously tested for nonspecific binding interactions and was found to display virtually no adverse results. These results represent important new steps in the development of the LSPR nanobiosensor for applications in medical diagnostics, biomedical research, and environmental science.
Details
- Title: Subtitle
- Nanoscale optical biosensors based on localized surface plasmon resonance spectroscopy
- Creators
- Amanda J Haes - Northwestern Univ. (USA)Richard P Van Duyne - Northwestern Univ. (USA)
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.5221(1), pp.47-58
- Conference
- Plasmonics: Metallic Nanostructures and Their Optical Properties
- DOI
- 10.1117/12.508308
- ISSN
- 0277-786X
- Language
- English
- Date published
- 11/03/2003
- Academic Unit
- Chemistry
- Record Identifier
- 9983985926302771
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