Conference proceeding
Oligomeric Proanthocyanidins from the barks of Cinnamomum verum and their dentin enhancement properties
Planta Medica, Vol.80(10)
American Society of Pharmacognosy 2014 Annual Meeting – Held in conjunction with the 14th Annual Oxford International Conference on the Science of Botanicals - Oxford, Mississippi, USA - 2014
07/14/2014
DOI: 10.1055/s-0034-1382433
Abstract
Proanthocyanidins (PACs) are one of the major classes of polyphenols which represent the condensed tannins consisting of oligomeric or polymeric flavan-3-ols. Dentin is a complex mineralized internal tissue of teeth. Intermolecular crosslinks between dentin and the proanthocyanidins enhance the biomechanical properties of the dentin. This study investigates the constituents of Cinnamon bark as a dentin biomodifier. After selecting a PAC oligomer fraction via a detailed bioassay-guided process, the phytochemical studies resulted in the isolation of a new A-type tetrameric PAC, epicatechin-(2
β
→O→7,4
β
→8)-epicatechin-(4
β
→6)-epicatechin-(2
β
→O→7,4
β
→8)-catechin (1) and the known trimer, epicatechin-(2
β
→O→7,4
β
→8)-epicatechin-(4
β
→8)-epicatechin (2). The structures of proanthocyanidins were assigned by a combination of HRESIMS, ECD, 1D and 2D NMR, and
1
H iterative Full Spin Analysis (HiFSA). HiFSA of this compound class was performed for the first time to enable rapid identification of congeneric compounds.
Fig. 1
Details
- Title: Subtitle
- Oligomeric Proanthocyanidins from the barks of Cinnamomum verum and their dentin enhancement properties
- Creators
- C Vidal - Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USAJ W Nam - Department of Medicinal Chemistry and Pharmacognosy, College of PharmacyR S Phansalkar - Department of Medicinal Chemistry and Pharmacognosy, College of PharmacyD C Lankin - Department of Medicinal Chemistry and Pharmacognosy, College of PharmacyS N Chen - Department of Medicinal Chemistry and Pharmacognosy, College of PharmacyJ B McAlpine - Department of Medicinal Chemistry and Pharmacognosy, College of PharmacyT Aguiar - Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USAA K Bedran-Russo - Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USAG F Pauli - Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy
- Resource Type
- Conference proceeding
- Publication Details
- Planta Medica, Vol.80(10)
- Conference
- American Society of Pharmacognosy 2014 Annual Meeting – Held in conjunction with the 14th Annual Oxford International Conference on the Science of Botanicals - Oxford, Mississippi, USA - 2014
- DOI
- 10.1055/s-0034-1382433
- ISSN
- 0032-0943
- eISSN
- 1439-0221
- Language
- English
- Date published
- 07/14/2014
- Academic Unit
- Operative Dentistry
- Record Identifier
- 9984065707502771
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