Conference proceeding
Patient-Specific Valve Dynamics Using 3D Fluid-Structure Interaction Modeling: Comparison Between Bicuspid and Tricuspid Aortic Valves
Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, Vol.1
ASME 2013 Summer Bioengineering Conference, Sunriver, Oregon, USA, Jun. 26 - 29, 2013
06/26/2013
DOI: 10.1115/SBC2013-14563
Abstract
Aortic valve diseases such as congenital bicuspid aortic valve (BAV) and progressive calcification in tricuspid valves affect the hemodynamics in the aortic arch. In addition to leaflet calcification, BAVs are associated with other ailments such as aortic coarctation, aneurysm and dissection [1]. It has also been observed that progressive calcification is accelerated in the case of BAVs compared to normal tricuspid valves. While it is not yet known whether the geometric distortion in BAVs is the main cause of calcification [2] in these valves, the distortion in the leaflets may give rise to altered stresses during the deformation processes which might play a role in accelerating the calcification process in BAVs. In addition, the altered flow caused by the change in geometry could alter the local fluid stresses during the opening phase, which might affect the endothelial lining of the aortic wall. Analyzing and comparing BAV and tricuspid aortic valves as a fluid-structure interaction problem will help determine the stress distribution on the leaflets during opening phase, and enable the examination of altered flow dynamics in the ascending aorta. In this study, the opening phase of a patient-specific bicuspid aortic valve is analyzed at physiological conditions and compared with the opening phase of a tricuspid aortic valve.
Details
- Title: Subtitle
- Patient-Specific Valve Dynamics Using 3D Fluid-Structure Interaction Modeling: Comparison Between Bicuspid and Tricuspid Aortic Valves
- Creators
- V Govindarajan - University of IowaJ Mousel - University of IowaS. C Vigmostad - University of IowaH. S Udaykumar - University of IowaM. M Levack - University of PennsylvaniaJ. H Gorman - University of PennsylvaniaB. M Jackson - University of PennsylvaniaR. C Gorman - University of PennsylvaniaK. B Chandran - University of Iowa
- Resource Type
- Conference proceeding
- Publication Details
- Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, Vol.1
- Conference
- ASME 2013 Summer Bioengineering Conference, Sunriver, Oregon, USA, Jun. 26 - 29, 2013
- DOI
- 10.1115/SBC2013-14563
- Publisher
- American Society of Mechanical Engineers
- Language
- English
- Date published
- 06/26/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Surgery; Injury Prevention Research Center; Mechanical Engineering
- Record Identifier
- 9984195177502771
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